Mosquitocidal Effect of Ivermectin-treated Nettings and Sprayed Walls on Anopheles Gambiae S.s

Overview

Journal Sci Rep

Specialty Science

Date 2024 Jun 1

PMID 38824239

Authors

Majidah Hamid-Adiamoh

Abdul Khalie Muhammad

Benoit Sessinou Assogba

Harouna Massire Soumare

Lamin Jadama

Moussa Diallo

Umberto DAlessandro

Mamadou Ousmane Ndiath

Annette Erhart

Alfred Amambua-Ngwa

Affiliations

Soon will be listed here.

Abstract

Ivermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle. Nevertheless, IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls. The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment. Laboratory-reared, insecticide-susceptible Kisumu Anopheles gambiae were exposed to IVM on impregnated netting materials and sprayed plastered- and mud walls using cone bioassays. The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM. The effect was slower on the IVM-sprayed walls compared to the treated nettings. Further work to evaluate possibility of IVM as a new insecticide formulation in LLINs and IRS will be required.

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