Water Channels in the Brain and Spinal Cord-overview of the Role of Aquaporins in Traumatic Brain Injury and Traumatic Spinal Cord Injury

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2024 May 31

PMID 38818518

Authors

Thea Overgaard Wichmann

Marie Hedegaard Hojsager

Helle Hasager Damkier

Affiliations

Soon will be listed here.

Abstract

Knowledge about the mechanisms underlying the fluid flow in the brain and spinal cord is essential for discovering the mechanisms implicated in the pathophysiology of central nervous system diseases. During recent years, research has highlighted the complexity of the fluid flow movement in the brain through a glymphatic system and a lymphatic network. Less is known about these pathways in the spinal cord. An important aspect of fluid flow movement through the glymphatic pathway is the role of water channels, especially aquaporin 1 and 4. This review provides an overview of the role of these aquaporins in brain and spinal cord, and give a short introduction to the fluid flow in brain and spinal cord during in the healthy brain and spinal cord as well as during traumatic brain and spinal cord injury. Finally, this review gives an overview of the current knowledge about the role of aquaporins in traumatic brain and spinal cord injury, highlighting some of the complexities and knowledge gaps in the field.

Citing Articles

The Crucial Role of the Blood-Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications.

Kim S, Jung U, Kim S J Clin Med. 2025; 14(2).

PMID: 39860392 PMC: 11765772. DOI: 10.3390/jcm14020386.

References

Garcia T, Jonak C, Binder D . The Role of Aquaporins in Spinal Cord Injury. Cells. 2023; 12(13). PMC: 10340765. DOI: 10.3390/cells12131701. View

Jin L, Li J, Wang K, Xia W, Zhu Z, Wang C . Blood-Spinal Cord Barrier in Spinal Cord Injury: A Review. J Neurotrauma. 2020; 38(9):1203-1224. DOI: 10.1089/neu.2020.7413. View

Louveau A, Herz J, Alme M, Salvador A, Dong M, Viar K . CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. 2018; 21(10):1380-1391. PMC: 6214619. DOI: 10.1038/s41593-018-0227-9. View

Kugler E, Greenwood J, MacDonald R . The "Neuro-Glial-Vascular" Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction. Front Cell Dev Biol. 2021; 9:732820. PMC: 8502923. DOI: 10.3389/fcell.2021.732820. View

McCaslin A, Chen B, Radosevich A, Cauli B, Hillman E . In vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling. J Cereb Blood Flow Metab. 2010; 31(3):795-806. PMC: 3063633. DOI: 10.1038/jcbfm.2010.204. View

Overgaard Wichmann T, Kasch H, Dyrskog S, Hoy K, Moller B, Krog J . Cerebrospinal fluid and peripheral blood proteomics in Traumatic Spinal Cord Injury: A prospective pilot study. Brain Spine. 2022; 2:100906. PMC: 9560581. DOI: 10.1016/j.bas.2022.100906. View

Kimura A, Hsu M, Seldin M, Verkman A, Scharfman H, Binder D . Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010; 67(6):794-801. DOI: 10.1002/ana.22023. View

Oshio K, Watanabe H, Yan D, Verkman A, Manley G . Impaired pain sensation in mice lacking Aquaporin-1 water channels. Biochem Biophys Res Commun. 2006; 341(4):1022-8. DOI: 10.1016/j.bbrc.2006.01.062. View

Jacob L, Boisserand L, Geraldo L, de Brito Neto J, Mathivet T, Antila S . Anatomy and function of the vertebral column lymphatic network in mice. Nat Commun. 2019; 10(1):4594. PMC: 6785564. DOI: 10.1038/s41467-019-12568-w. View

10.

Overgaard Wichmann T, Kasch H, Dyrskog S, Hoy K, Moller B, Krog J . The inflammatory response and blood-spinal cord barrier integrity in traumatic spinal cord injury: a prospective pilot study. Acta Neurochir (Wien). 2022; 164(12):3143-3153. DOI: 10.1007/s00701-022-05369-6. View

11.

Johnson W, Griswold D . Traumatic brain injury: a global challenge. Lancet Neurol. 2017; 16(12):949-950. DOI: 10.1016/S1474-4422(17)30362-9. View

12.

Woollam D, Millen J . The perivascular spaces of the mammalian central nervous system and their relation to the perineuronal and subarachnoid spaces. J Anat. 1955; 89(2):193-200. PMC: 1244781. View

13.

Jarrahi A, Braun M, Ahluwalia M, Gupta R, Wilson M, Munie S . Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions. Biomedicines. 2020; 8(10). PMC: 7601301. DOI: 10.3390/biomedicines8100389. View

14.

Nesic O, Lee J, Johnson K, Ye Z, Xu G, Unabia G . Transcriptional profiling of spinal cord injury-induced central neuropathic pain. J Neurochem. 2005; 95(4):998-1014. DOI: 10.1111/j.1471-4159.2005.03462.x. View

15.

Brodin P, Davis M . Human immune system variation. Nat Rev Immunol. 2016; 17(1):21-29. PMC: 5328245. DOI: 10.1038/nri.2016.125. View

16.

Nesic O, Lee J, Unabia G, Johnson K, Ye Z, Vergara L . Aquaporin 1 - a novel player in spinal cord injury. J Neurochem. 2008; 105(3):628-40. PMC: 2634749. DOI: 10.1111/j.1471-4159.2007.05177.x. View

17.

Hablitz L, Pla V, Giannetto M, Vinitsky H, Staeger F, Metcalfe T . Circadian control of brain glymphatic and lymphatic fluid flow. Nat Commun. 2020; 11(1):4411. PMC: 7468152. DOI: 10.1038/s41467-020-18115-2. View

18.

Halsey A, Conner A, Bill R, Logan A, Ahmed Z . Aquaporins and Their Regulation after Spinal Cord Injury. Cells. 2018; 7(10). PMC: 6210264. DOI: 10.3390/cells7100174. View

19.

Saadoun S, Bell B, Verkman A, Papadopoulos M . Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice. Brain. 2008; 131(Pt 4):1087-98. DOI: 10.1093/brain/awn014. View

20.

. Global, regional, and national burden of spinal cord injury, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2023; 22(11):1026-1047. PMC: 10584692. DOI: 10.1016/S1474-4422(23)00287-9. View