Juvenile Idiopathic Arthritis and Primary Ovarian Failure: a Two-sample Mendelian Randomization Analysis in a Mixed-gender Cohort

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2024 May 31

PMID 38818501

Authors

Yuanhang Mo

Anquan Shang

Guoguo Wei

Donghui Xu

Yuxi Hou

Xiaowen Shao

Chaoyan Yue

Affiliations

Soon will be listed here.

Abstract

Background: The causal relationship between juvenile idiopathic arthritis (JIA) and primary ovarian failure (POF) remains uncertain. To elucidate this relationship, we employed a two-sample Mendelian randomization analysis.

Methods: The single nucleotide polymorphisms (SNPs) associated with JIA were obtained from a previously published genome-wide association study (GWAS), while the pooled data for POF originated from the FinnGen consortium. The study populations consisted exclusively of individuals of European descent. In our Mendelian randomization analysis, we performed inverse-variance weighted analysis, weighted-median analysis, weighted-mode analysis and Mendelian randomization-Egger regression analysis, supplemented by sensitivity analyses to validate the accuracy and robustness of the findings.

Results: The IVW (OR = 1.23, 95% CI 1.06-1.43; P = 0.007) and weighted median (OR = 1.25, 95% CI 1.06-1.47; P = 0.009), along with sensitivity analysis validation, provide compelling evidence of a significant causal association between JIA and POF.

Conclusion: The study revealed a significant causal association between genetically predicted JIA and POF, indicating that JIA significantly elevates the risk of developing POF. Therefore, it is recommended to implement screening for premature ovarian failure in women diagnosed with JIA.

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