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Enantioconvergent Synthesis of Chiral Fluorenols from Racemic Secondary Alcohols Pd(ii)/chiral Norbornene Cooperative Catalysis

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Journal Chem Sci
Specialty Chemistry
Date 2024 May 31
PMID 38817591
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Abstract

An efficient protocol for the asymmetric synthesis of fluorenols has been developed through an enantioconvergent process enabled by Pd(ii)/chiral norbornene cooperative catalysis. This approach allows facile access to diverse functionalized chiral fluorenols with constantly excellent enantioselectivities, applying readily available racemic secondary -bromobenzyl alcohols and aryl iodides as the starting materials.

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