Effect of Pentoxifylline on Endothelial Dysfunction, Oxidative Stress and Inflammatory Markers in STEMI Patients

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2024 May 31

PMID 38817362

Authors

Asmaa Saeed

Mohamed Moustafa Farouk

Nagwa Ali Sabri

Mohamed Ayman Saleh

Marwa Adel Ahmed

Affiliations

Soon will be listed here.

Abstract

ST-elevation myocardial infarction (STEMI) patients suffer higher mortality and adverse outcomes linked to endothelial dysfunction (ED). 43 patients were randomized to pentoxifylline (PTX) 400 mg thrice daily (n = 22) or placebo (n = 21). Soluble vascular cell adhesion molecule-1, malondialdehyde, interleukin-1 (IL-1), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were assessed at baseline and 2 months. After 2 months, no significant difference was observed in markers' levels between the 2 groups. However, a within-group comparison revealed a statistically significant change in hs-CRP in the PTX group (10.057 (9.779-10.331) versus 9.721 (6.102-10.191)), p = 0.032. PTX for 2 months in STEMI patients was safe and well-tolerated but had no significant detectable effect on ED, oxidative stress or inflammatory markers. NCT04367935 (ClinicalTrials.gov).

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