Hydrogen Peroxide in Breast Milk is Crucial for Gut Microbiota Formation and Myelin Development in Neonatal Mice

Overview

Journal Gut Microbes

Specialties Gastroenterology
Microbiology

Date 2024 May 31

PMID 38816999

Authors

Jun Kambe

Kento Usuda

Ryo Inoue

Kazuhiko Hirayama

Masahiko Ito

Ken Suenaga

Sora Masukado

Hong Liu

Shiho Miyata

Chunmei Li

Ikuo Kimura

Yuki Yamamoto

Kentaro Nagaoka

Affiliations

Soon will be listed here.

Abstract

Early life environment influences mammalian brain development, a growing area of research within the Developmental Origins of Health and Disease framework, necessitating a deeper understanding of early life factors on children's brain development. This study introduces a mouse model, knockout mice, to investigate the relationship between breast milk, the gut microbiome, and brain development. The results reveal that breast milk's reactive oxygen species (ROS) are vital in shaping the neonatal gut microbiota. Decreased hydrogen peroxide (HO) levels in milk disrupt the gut microbiome and lead to abnormal metabolite production, including D-glucaric acid. This metabolite inhibits hippocampal myelin formation during infancy, potentially contributing to behavioral abnormalities observed in adulthood. These findings suggest that HO in breast milk is crucial for normal gut microbiota formation and brain development, with implications for understanding and potentially treating neurodevelopmental disorders in humans.

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