Antitumor Progenitor Exhausted CD8 T Cells Are Sustained by TCR Engagement

Overview

Journal Nat Immunol

Date 2024 May 30

PMID 38816618

Authors

Xin Lan

Tian Mi

Shanta Alli

Cliff Guy

Mohamed Nadhir Djekidel

Xueyan Liu

Shannon Boi

Partha Chowdhury

Minghong He

Dietmar Zehn

Yongqiang Feng

Ben Youngblood

Affiliations

Soon will be listed here.

Abstract

The durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a resource for replenishing effector T cells and preserve their quantity through self-renewal. However, it is unknown how T cell receptor (TCR) engagement affects the self-renewal capacity of Tpex in settings of continued antigen exposure. Here we use a Lewis lung carcinoma model that elicits either optimal or attenuated TCR signaling in CD8 T cells to show that formation of Tpex in tumor-draining lymph nodes and their intratumoral persistence is dependent on optimal TCR engagement. Notably, attenuated TCR stimulation accelerates the terminal differentiation of optimally primed Tpex. This TCR-reinforced Tpex development and self-renewal is coupled to proximal positioning to dendritic cells and epigenetic imprinting involving increased chromatin accessibility at Egr2 and Tcf1 target loci. Collectively, this study highlights the critical function of TCR engagement in sustaining Tpex during tumor progression.

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