» Articles » PMID: 38813557

Virtual Realities, Real Recoveries: Exploring the Efficacy of 3MDR Therapy for Treatment-resistant PTSD

Overview
Journal Front Psychol
Date 2024 May 30
PMID 38813557
Authors
Affiliations
Soon will be listed here.
Abstract

Exposure-based therapies have shown promise in treating post-traumatic stress disorder (PTSD), but challenges exist in maintaining patient engagement and finding appropriate stimuli for graded exposure. Virtual reality (VR) technology has been used to enhance exposure therapy, but current software lacks customization and some patients remain treatment-resistant. A novel approach called multimodular motion-assisted memory desensitization and reconsolidation (3MDR) has the potential to solve some of the current limitations of VR-assisted exposure therapy. This study examines the efficacy of 3MDR treatment for individuals with treatment-resistant PTSD through a systematic review of relevant literature and clinical studies. Preliminary findings indicate promise for 3MDR in reducing PTSD symptoms, including emotional regulation and moral injury. However, further research with larger samples and controlled studies is needed to understand underlying mechanisms and validate these results. Moreover, this study highlights the importance of health-economic evaluations to assess costs and resource utilization associated with implementing 3MDR treatment in clinical services.

References
1.
Steenkamp M, Litz B, Hoge C, Marmar C . Psychotherapy for Military-Related PTSD: A Review of Randomized Clinical Trials. JAMA. 2015; 314(5):489-500. DOI: 10.1001/jama.2015.8370. View

2.
Feder A, Costi S, Rutter S, Collins A, Govindarajulu U, Jha M . A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder. Am J Psychiatry. 2021; 178(2):193-202. DOI: 10.1176/appi.ajp.2020.20050596. View

3.
Nijdam M, Vermetten E . Moving forward in treatment of posttraumatic stress disorder: innovations to exposure-based therapy. Eur J Psychotraumatol. 2018; 9(1):1458568. PMC: 5965022. DOI: 10.1080/20008198.2018.1458568. View

4.
Xi K, Xiao H, Huang X, Yuan Z, Liu M, Mao H . Reversal of hyperactive higher-order thalamus attenuates defensiveness in a mouse model of PTSD. Sci Adv. 2023; 9(5):eade5987. PMC: 9897664. DOI: 10.1126/sciadv.ade5987. View

5.
Koenig H, Youssef N, Ames D, Teng E, Hill T . Examining the Overlap Between Moral Injury and PTSD in US Veterans and Active Duty Military. J Nerv Ment Dis. 2019; 208(1):7-12. DOI: 10.1097/NMD.0000000000001077. View