Association of Periodontal Red Complex Bacteria With the Incidence of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 May 30

PMID 38813341

Authors

Sriram Kaliamoorthy

Sugantha Priya Sayeeram

N Gowdhaman

Merlin Jayaraj

B Radhika

Sugirtha Chellapandi

Agila Elumalai

Sai P Archana

Kanmani Raju

Santosh Palla

Affiliations

Soon will be listed here.

Abstract

is the primary microbe in the "periodontal red complex" bacteria (PRCB) along with and , which are linked to periodontal disease (PD). These pathogens are also implicated in various systemic disorders, but their association with the incidence of gastrointestinal (GI) cancer is less explored. A systematic review followed by a meta-analysis was conducted as per standard guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2022) to find this association between GI cancers and PRCB after a literature search for full-text papers in the English language (between 2010 and 2023) in databases (Cochrane Library, PubMed, and Web of Science) with suitable keywords using the Boolean search strategy. Data extraction involved titles, abstracts, and full texts retrieved and scored by the modified Newcastle-Ottawa Scale. The data were analyzed by the Review Manager (RevMan 5.2, Cochrane Collaboration, Denmark). Standard Cochran Q test and I statistics (for heterogeneity) and a random effects model (pooled OR with 95% CI) were applied to report results. among the PRCB was linked to GI cancers (OR: 2.16; 95% CI: 1.34-3.47). and did not show meaningful associations as per existing evidence for GI cancers.

References

Hiraki D, Uehara O, Kuramitsu Y, Morikawa T, Harada F, Yoshida K . Lipopolysaccharide Stimulates the Upregulated Expression of the Pancreatic Cancer-Related Genes Regenerating Islet-Derived 3 A/G in Mouse Pancreas. Int J Mol Sci. 2020; 21(19). PMC: 7583020. DOI: 10.3390/ijms21197351. View

Pourhoseingholi M, Vahedi M, Baghestani A . Burden of gastrointestinal cancer in Asia; an overview. Gastroenterol Hepatol Bed Bench. 2015; 8(1):19-27. PMC: 4285928. View

Stasiewicz M, Karpinski T . The oral microbiota and its role in carcinogenesis. Semin Cancer Biol. 2021; 86(Pt 3):633-642. DOI: 10.1016/j.semcancer.2021.11.002. View

Kylma A, Jouhi L, Listyarifah D, Mohamed H, Makitie A, Remes S . Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma. Br J Cancer. 2018; 119(1):89-95. PMC: 6035174. DOI: 10.1038/s41416-018-0143-5. View

Peters B, Wu J, Pei Z, Yang L, Purdue M, Freedman N . Oral Microbiome Composition Reflects Prospective Risk for Esophageal Cancers. Cancer Res. 2017; 77(23):6777-6787. PMC: 5726431. DOI: 10.1158/0008-5472.CAN-17-1296. View

Fan X, Alekseyenko A, Wu J, Peters B, Jacobs E, Gapstur S . Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2016; 67(1):120-127. PMC: 5607064. DOI: 10.1136/gutjnl-2016-312580. View

Zhang Y, Niu Q, Fan W, Huang F, He H . Oral microbiota and gastrointestinal cancer. Onco Targets Ther. 2019; 12:4721-4728. PMC: 6592037. DOI: 10.2147/OTT.S194153. View

Wei W, Li J, Shen X, Lyu J, Yan C, Tang B . Oral Microbiota from Periodontitis Promote Oral Squamous Cell Carcinoma Development via γδ T Cell Activation. mSystems. 2022; 7(5):e0046922. PMC: 9600543. DOI: 10.1128/msystems.00469-22. View

Michaud D, Izard J, Wilhelm-Benartzi C, You D, Grote V, Tjonneland A . Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study. Gut. 2012; 62(12):1764-70. PMC: 3815505. DOI: 10.1136/gutjnl-2012-303006. View

10.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009; 62(10):e1-34. DOI: 10.1016/j.jclinepi.2009.06.006. View

11.

Kaliamoorthy S, Nagarajan M, Sethuraman V, Jayavel K, Lakshmanan V, Palla S . Association of Alzheimer's disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies. Med Pharm Rep. 2022; 95(2):144-151. PMC: 9176309. DOI: 10.15386/mpr-2278. View

12.

Bourgeois D, Inquimbert C, Ottolenghi L, Carrouel F . Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease-Is There Cause for Consideration?. Microorganisms. 2019; 7(10). PMC: 6843669. DOI: 10.3390/microorganisms7100424. View

13.

Jardim S, de Souza L, de Souza H . The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?. Int J Environ Res Public Health. 2023; 20(4). PMC: 9962127. DOI: 10.3390/ijerph20043640. View

14.

Mu W, Jia Y, Chen X, Li H, Wang Z, Cheng B . Intracellular Promotes the Proliferation of Colorectal Cancer Cells the MAPK/ERK Signaling Pathway. Front Cell Infect Microbiol. 2021; 10:584798. PMC: 7785964. DOI: 10.3389/fcimb.2020.584798. View

15.

Sobocki B, Basset C, Bruhn-Olszewska B, Olszewski P, Szot O, Kazmierczak-Siedlecka K . Molecular Mechanisms Leading from Periodontal Disease to Cancer. Int J Mol Sci. 2022; 23(2). PMC: 8778447. DOI: 10.3390/ijms23020970. View

16.

Yao Y, Shen X, Zhou M, Tang B . Periodontal Pathogens Promote Oral Squamous Cell Carcinoma by Regulating ATR and NLRP3 Inflammasome. Front Oncol. 2021; 11:722797. PMC: 8514820. DOI: 10.3389/fonc.2021.722797. View

17.

Zhou Y, Luo G . and digestive system cancers. World J Clin Cases. 2019; 7(7):819-829. PMC: 6473131. DOI: 10.12998/wjcc.v7.i7.819. View

18.

Nicolae F, Didilescu A, Surlin P, Ungureanu B, Surlin V, Patrascu S . Subgingival Periopathogens Assessment and Clinical Periodontal Evaluation of Gastric Cancer Patients-A Cross Sectional Pilot Study. Pathogens. 2022; 11(3). PMC: 8949055. DOI: 10.3390/pathogens11030360. View

19.

Wroblewski L, Peek Jr R, Wilson K . Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010; 23(4):713-39. PMC: 2952980. DOI: 10.1128/CMR.00011-10. View

20.

Kong J, Liu Y, Qian M, Xing L, Gao S . The relationship between and oesophageal squamous cell carcinoma: a literature review. Epidemiol Infect. 2023; 151:e69. PMC: 10204138. DOI: 10.1017/S0950268823000298. View