Hematological Ratios and Indices in Canine Large B-cell Lymphoma

Overview

Journal Open Vet J

Specialty Veterinary Medicine

Date 2024 May 29

PMID 38808287

Authors

Alessandra Gavazza

Valentina Cremonini

Arianna Miglio

Chiara Starita

Giacomo Rossi

Maria Teresa Antognoni

Affiliations

Soon will be listed here.

Abstract

Background: Canine lymphoma is the most common hematopoietic cancer in dogs. Numerous studies have evaluated the prognostic value of hematological abnormalities and ratios in both humans and dogs with lymphoma.

Aim: To compare hematological parameters and complete blood count ratios between a population of dogs affected by lymphoma and healthy dogs to identify potential prognostic markers for lymphoma.

Methods: This retrospective case-control study compares hematological parameters and complete blood count ratios between a population of 114 dogs affected by multicentric large B-cell lymphoma (LBCL) and 60 healthy dogs.

Results: The study found several statistically significant differences between the hematological indices of LBCL dogs and healthy dogs, but no correlation between these parameters and the survival times of 78 dogs treated with chemotherapy Madison Wisconsin protocol. In addition, hematological alterations were evaluated such as anemia, leukocytosis, and thrombocytopenia.

Conclusion: Hematological ratios have been suggested as potential prognostic markers for canine LBCL but their real prognostic value remains controversial and requires future investigation.

Citing Articles

Clinical significance of blood cell ratios in healthy and sick Leishmania infantum-seropositive dogs.

Donato G, Baxarias M, Solano-Gallego L, Martinez-Florez I, Mateu C, Pennisi M Parasit Vectors. 2024; 17(1):435.

PMID: 39444011 PMC: 11515770. DOI: 10.1186/s13071-024-06522-z.

References

Forget P, Khalifa C, Defour J, Latinne D, Van Pel M, De Kock M . What is the normal value of the neutrophil-to-lymphocyte ratio?. BMC Res Notes. 2017; 10(1):12. PMC: 5217256. DOI: 10.1186/s13104-016-2335-5. View

Miglio A, Gavazza A, Siepi D, Bagaglia F, Misia A, Antognoni M . Hematological and Biochemical Reference Intervals for 5 Adult Hunting Dog Breeds Using a Blood Donor Database. Animals (Basel). 2020; 10(7). PMC: 7401625. DOI: 10.3390/ani10071212. View

Zhou S, Fang F, Chen H, Zhang W, Chen Y, Shi Y . Prognostic significance of the red blood cell distribution width in diffuse large B-cell lymphoma patients. Oncotarget. 2017; 8(25):40724-40731. PMC: 5522205. DOI: 10.18632/oncotarget.16560. View

Martinez C, Mooney C, Shiel R, Tang P, Mooney L, ONeill E . Evaluation of red blood cell distribution width in dogs with various illnesses. Can Vet J. 2019; 60(9):964-971. PMC: 6697020. View

Perisa V, Zibar L, Sincic-Petricevic J, Knezovic A, Perisa I, Barbic J . Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study. Croat Med J. 2015; 56(4):334-43. PMC: 4576747. DOI: 10.3325/cmj.2015.56.334. View

Faroni E, Sabattini S, Lenzi J, Guerra D, Comazzi S, Aresu L . Sleeping Beauty: Anesthesia May Promote Relapse in Dogs With Diffuse Large B-Cell Lymphoma in Complete Remission After Chemo-Immunotherapy. Front Vet Sci. 2021; 8:760603. PMC: 8645585. DOI: 10.3389/fvets.2021.760603. View

Balta S, Ozturk C, Balta I, Demirkol S, Demir M, Celik T . The Neutrophil-Lymphocyte Ratio and Inflammation. Angiology. 2015; 67(3):298-9. DOI: 10.1177/0003319715615252. View

Henriques J, Felisberto R, Constantino-Casas F, Cabecadas J, Dobson J . Peripheral blood cell ratios as prognostic factors in canine diffuse large B-cell lymphoma treated with CHOP protocol. Vet Comp Oncol. 2020; 19(2):242-252. DOI: 10.1111/vco.12668. View

Elinav E, Nowarski R, Thaiss C, Hu B, Jin C, Flavell R . Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013; 13(11):759-71. DOI: 10.1038/nrc3611. View

10.

Yilmaz B, Sengul E, Gul A, Alabalik U, Ozkurt F, Akdag M . Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Laryngeal Carcinoma. Indian J Otolaryngol Head Neck Surg. 2018; 70(2):175-179. PMC: 6015577. DOI: 10.1007/s12070-014-0769-4. View

11.

Vos N, Pellin M, Vail D . A comparison of 12- and 19-week CHOP protocols using non-randomized, contemporaneous controls. Vet Comp Oncol. 2019; 17(3):276-284. DOI: 10.1111/vco.12465. View

12.

Rejec A, Butinar J, Gawor J, Petelin M . Evaluation of Complete Blood Count Indices (NLR, PLR, MPV/PLT, and PLCRi) in Healthy Dogs, Dogs With Periodontitis, and Dogs With Oropharyngeal Tumors as Potential Biomarkers of Systemic Inflammatory Response. J Vet Dent. 2017; 34(4):231-240. DOI: 10.1177/0898756417731775. View

13.

Antognoni M, Misia A, Brachelente C, Mechelli L, Paolini A, Miglio A . Non Epitheliotropic B-Cell Lymphoma with Plasmablastic Differentiation vs. Cutaneous Plasmacytosis in a 12-Years-Old Beagle: Case Presentation and Clinical Review. Vet Sci. 2021; 8(12). PMC: 8707514. DOI: 10.3390/vetsci8120317. View

14.

Wan J, Wang X, Zhen Y, Chen X, Yao P, Liu W . The predictive role of the neutrophil-lymphocyte ratio in the prognosis of adult patients with stroke. Chin Neurosurg J. 2020; 6:22. PMC: 7398197. DOI: 10.1186/s41016-020-00201-5. View

15.

Geffre A, Friedrichs K, Harr K, Concordet D, Trumel C, Braun J . Reference values: a review. Vet Clin Pathol. 2009; 38(3):288-98. DOI: 10.1111/j.1939-165X.2009.00179.x. View

16.

Curran K, Thamm D . Retrospective analysis for treatment of naïve canine multicentric lymphoma with a 15-week, maintenance-free CHOP protocol. Vet Comp Oncol. 2015; 14 Suppl 1:147-55. DOI: 10.1111/vco.12163. View

17.

Alaimo C, De Feo G, Lubas G, Gavazza A . Utility and prognostic significance of leukocyte ratios in dogs with Primary Immune-Mediated Hemolytic Anemia. Vet Res Commun. 2022; 47(1):305-310. DOI: 10.1007/s11259-022-09935-2. View

18.

Gavazza A, Lubas G, Valori E, Gugliucci B . Retrospective survey of malignant lymphoma cases in the dog: clinical, therapeutical and prognostic features. Vet Res Commun. 2008; 32 Suppl 1:S291-3. DOI: 10.1007/s11259-008-9131-1. View

19.

Korniluk A, Koper-Lenkiewicz O, Kaminska J, Kemona H, Dymicka-Piekarska V . Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019; 2019:9213074. PMC: 6501263. DOI: 10.1155/2019/9213074. View

20.

Davies O, Szladovits B, Polton G, Garden O, Leo C, Lara-Garcia A . Prognostic significance of clinical presentation, induction and rescue treatment in 42 cases of canine centroblastic diffuse large B-cell multicentric lymphoma in the United Kingdom. Vet Comp Oncol. 2017; 16(2):276-287. DOI: 10.1111/vco.12378. View