Prevalence and Risk Factors of Depression Among Patients with Perianal Fistulizing Crohn's Disease

Overview

Journal World J Psychiatry

Publisher Baishideng Publishing Group

Specialty Psychiatry

Date 2024 May 29

PMID 38808090

Authors

Jing Li

Wing-Yi Ng

Li-Chao Qiao

Fen Yuan

Xing Lan

Li-Bei Zhu

Bo-Lin Yang

Zhong-Qiu Wang

Affiliations

Soon will be listed here.

Abstract

Background: Psychological distress, especially depression, associated with perianal fistulizing Crohn's disease (PFCD) is widespread and refractory. However, there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with PFCD.

Aim: To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with PFCD.

Methods: The study was conducted in the form of survey and clinical data collection questionnaire and specialized medical staff. Depressive symptoms, life quality, and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9, Inflammatory Bowel Disease Patient Quality of Life Questionnaire (IBDQ), and Inflammatory Bowel Disease (IBD) Fatigue Patient Self-assessment Scale. The basic demographic information, overall disease features, perianal clinical information, and laboratory inflammation indicators were also gathered. Multivariate regression analysis was ultimately used to ascertain the risk factors of depression associated with PFCD.

Results: A total of 123 patients with PFCD were involved, and 56.91% were suffering from depression. According to multivariate logistic regression analysis, Perianal Disease Activity Index (PDAI) score [odds ratio (OR) = 0.69, 95% confidence interval (CI): 0.50 to 0.95], IBDQ score (OR = 0.93, 95%CI: 0.88 to 0.97), modified Van Assche index (OR = 1.24, 95%CI: 1.01 to 1.53), and IBD Fatigue score (OR = 1.72, 95%CI: 1.23 to 2.42) were independent risk factors of depression-related prevalence among patients with PFCD ( < 0.05). Multiple linear regression analysis revealed that the increasing perianal modified Van Assche index ( value = 0.166, 95%CI: 0.02 to 0.31) and decreasing IBDQ score ( value = -0.116, 95%CI: -0.14 to -0.09) were independently associated with the severity of depression ( < 0.05).

Conclusion: Depressive symptoms in PFCD patients have significantly high prevalence. PDAI score, modified Van Assche index, quality of life, and fatigue severity were the main independent risk factors.

Citing Articles

Rapid Resolution of Perianal Crohn's Disease with Upadacitinib.

Brennan K, Beniwal-Patel P ACG Case Rep J. 2025; 12(2):e01623.

PMID: 39963477 PMC: 11832199. DOI: 10.14309/crj.0000000000001623.

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