Toxicity of UV Filter Benzophenone-3 in Brine Shrimp Nauplii () and Zebrafish () Embryos

Overview

Journal J Xenobiot

Date 2024 May 28

PMID 38804285

Authors

Melissa I Ortiz-Roman

Ileska M Casiano-Muniz

Felix R Roman-Velazquez

Affiliations

Soon will be listed here.

Abstract

The benzophenone (BP) family, including oxybenzone (BP-3), a prevalent sunscreen ingredient and environmental contaminant, has raised concerns since the year 2005. This study investigated oxybenzone toxicity in zebrafish () eleutheroembryos and brine shrimp () nauplii, focusing on the LC and developmental impacts. Zebrafish embryos (0.100-1.50 mg/L BP-3, 96 h) and (0.100-5.00 mg/L BP-3, 48 h) were tested with ultrasound-assisted emulsified liquid-phase microextraction (UA-ELPME) used for zebrafish tissue analysis. HPLC-DAD determined BP-3 concentrations (highest: 0.74 ± 0.13 mg/L). Although no significant zebrafish embryo mortality or hatching changes occurred, developmental effects were evident. Lethal concentrations were determined ( LC at 24 h = 3.19 ± 2.02 mg/L; embryos LC at 24 h = 4.19 ± 3.60 mg/L), with malformations indicating potential teratogenic effects. displayed intestinal tract alterations and embryos exhibited pericardial edema and spinal deformities. These findings highlight oxybenzone's environmental risks, posing threats to species and ecosystem health.

Citing Articles

Multigenerational Consequences of Prenatal Exposure to Benzophenone-3 Demonstrate Sex- and Region-Dependent Neurotoxic and Pro-Apoptotic Effects in Mouse Brain.

Przepiorska-Dronska K, Lach A, Pietrzak-Wawrzynska B, Rzemieniec J, Kajta M, Wawrzczak-Bargiela A Toxics. 2025; 12(12.

PMID: 39771121 PMC: 11728767. DOI: 10.3390/toxics12120906.

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