Evaluation of Liver Regeneration After Hemi-hepatectomy by Combining Computed Tomography and Post-operative Liver Function

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 May 28

PMID 38803961

Authors

Wenzhi Shu

Yisu Song

Zuyuan Lin

Mengfan Yang

Binhua Pan

Renyi Su

Modan Yang

Zhengyang Lu

Shusen Zheng

Xiao Xu

Zhe Yang

Xuyong Wei

Affiliations

Soon will be listed here.

Abstract

Background: Accurate evaluation of postoperative liver regeneration is essential to prevent postoperative liver failure.

Aims: To analyze the predictors that affect liver regeneration after hemi-hepatectomy.

Method: Patients who underwent hemi-hepatectomy in Hangzhou First People's Hospital and Hangzhou Shulan Hospital from January 2016 to December 2021 were enrolled in this study. The regeneration index (RI) was calculated by the following equation: RI = [(postoperative total liver volume {TLV} - future liver remnant volume {FLRV}/FLRV] × 100 %. Hepatic dysfunction was defined according to the "TBilpeak>7" standard, which was interpreted as (peak) total bilirubin (TBil) >7.0 mg/dL. Good liver regeneration was defined solely when the RI surpassed the median with hepatic dysfunction. Logistic regression analyses were performed to estimate prognostic factors affecting liver regeneration.

Result: A total of 153 patients were enrolled, with 33 in the benign group and 120 patients in the malignant group. In the entire study population, FLRV% [OR 4.087 (1.405-11.889), P = 0.010], international normalized ratio (INR) [OR 2.763 (95%CI, 1.008-7.577), P = 0.048] and TBil [OR 2.592 (95%CI, 1.177-5.710), P = 0.018] were independent prognostic factors associated with liver regeneration. In the benign group, only the computed tomography (CT) parameter FLRV% [OR, 11.700 (95%CI, 1.265-108.200), P = 0.030] predicted regeneration. In the malignant group, parenchymal hepatic resection rate (PHRR%) [OR 0.141 (95%CI, 0.040-0.499), P = 0.002] and TBil [OR 3.384 (95%CI, 1.377-8.319), P = 0.008] were independent prognostic factors.

Conclusion: FLRV%, PHRR%, TBil and INR were predictive factors associated with liver regeneration.

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