Esophageal Melanocytosis

Overview

Journal Autops Case Rep

Date 2024 May 28

PMID 38803486

Authors

Samikshya Thapa

Gajendra Kumar Yadav

Ratna Mondal

Ravi Hari Phulware

Affiliations

Soon will be listed here.

Abstract

Esophageal melanocytosis is a rare entity defined by the proliferation of a melanocytic basal layer of the esophageal squamous lining and deposition of melanin in the esophageal mucosa. Esophageal melanocytosis is considered a benign entity of unknown etiology; however, it has been reported as a melanoma precursor. We report a case of esophageal melanocytosis in a diabetic and hypertensive 67-year-old male with recurrent dizziness and syncope for the past 6 months. Given his complaint of dyspepsia, he underwent an upper gastrointestinal endoscopy, in which an esophageal biopsy revealed the diagnosis of esophageal melanocytosis. The definitive diagnosis of esophageal melanocytosis can only be made by histological analysis. The histologic differential diagnoses include melanocytic nevi and malignant melanoma. Therefore, they need to be ruled out.

References

Mori A, Tanaka M, Terasawa K, Hayashi S, Shimada Y . A magnified endoscopic view of esophageal melanocytosis. Gastrointest Endosc. 2005; 61(3):479-81. DOI: 10.1016/s0016-5107(04)02638-0. View

Yamazaki K, Ohmori T, Kumagai Y, Makuuchi H, Eyden B . Ultrastructure of oesophageal melanocytosis. Virchows Arch A Pathol Anat Histopathol. 1991; 418(6):515-22. DOI: 10.1007/BF01606502. View

Rodriguez Fernandez L, Garcia Sanchez M, Prieto de Paula J, Miramontes Gonzalez J . Black esophagus and diabetes: a close relationship. Cardiovasc Endocrinol Metab. 2021; 10(1):59-61. PMC: 7901817. DOI: 10.1097/XCE.0000000000000221. View

Ishida M, Mochizuki Y, Iwai M, Yoshida K, Kagotani A, Okabe H . Pigmented squamous intraepithelial neoplasia of the esophagus. Int J Clin Exp Pathol. 2013; 6(9):1868-73. PMC: 3759494. View

Chang F, Deere H . Esophageal melanocytosis morphologic features and review of the literature. Arch Pathol Lab Med. 2006; 130(4):552-7. DOI: 10.5858/2006-130-552-EMMFAR. View

DE LA PAVA S, NIGOGOSYAN G, PICKREN J, Cabrera A . Melanosis of the esophagus. Cancer. 1963; 16:48-50. DOI: 10.1002/1097-0142(196301)16:1<48::aid-cncr2820160107>3.0.co;2-m. View

Changela K, Reddy M . Smoker's melanosis: Isolated pigmented lesion in the laryngopharynx and esophagus. Turk J Gastroenterol. 2017; 28(6):524-525. DOI: 10.5152/tjg.2017.17186. View

Agarwal S A, Gnanamoorthy K, K A, Athani A . Esophageal Melanosis: An Unknown Entity. Cureus. 2022; 14(9):e29064. PMC: 9554602. DOI: 10.7759/cureus.29064. View

Walter A, van Rees B, Heijnen B, van Lanschot J, Offerhaus G . Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus. Virchows Arch. 2000; 437(2):203-7. DOI: 10.1007/s004280000220. View

10.

Gordon P, Mansur C, Gilchrest B . Regulation of human melanocyte growth, dendricity, and melanization by keratinocyte derived factors. J Invest Dermatol. 1989; 92(4):565-72. DOI: 10.1111/1523-1747.ep12709595. View

11.

GHADIALLY F, Walley V . Melanoses of the gastrointestinal tract. Histopathology. 1994; 25(3):197-207. DOI: 10.1111/j.1365-2559.1994.tb01319.x. View

12.

Vakharia B, Pietruk T, Calzada R . Anthracosis of the esophagus. Gastrointest Endosc. 1990; 36(6):615-7. DOI: 10.1016/s0016-5107(90)71181-9. View

13.

Kim S, Jeong J, Kim J, Koh S, Kim B, Lee K . Clinical and endoscopic characteristics of drug-induced esophagitis. World J Gastroenterol. 2014; 20(31):10994-9. PMC: 4138480. DOI: 10.3748/wjg.v20.i31.10994. View

14.

Destek S, Gul V, Ahioglu S, Erbil Y . A Rare Disease of the Digestive Tract: Esophageal Melanosis. Gastroenterology Res. 2016; 9(2-3):56-60. PMC: 5040545. DOI: 10.14740/gr670w. View

15.

Maroy B, Baylac F . Primary malignant esophageal melanoma arising from localized benign melanocytosis. Clin Res Hepatol Gastroenterol. 2012; 37(2):e65-7. DOI: 10.1016/j.clinre.2012.08.003. View

16.

Tzung-Ju L, Tsai-Wang H, Shih-Chun L . Primary malignant melanoma of the esophagus. Ann Saudi Med. 2008; 28(6):458-60. PMC: 6074247. DOI: 10.5144/0256-4947.2008.458. View

17.

Yokoyama A, Omori T, Yokoyama T, Tanaka Y, Mizukami T, Matsushita S . Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men. J Gastroenterol. 2005; 40(7):676-84. DOI: 10.1007/s00535-005-1610-3. View