Pleuroparenchymal Fibroelastosis As a Late-Onset Pulmonary Toxicity After Treatment with Anticancer Chemotherapy for High-Risk Neuroblastoma

Overview

Journal Case Rep Pediatr

Publisher Wiley

Specialty Pediatrics

Date 2024 May 27

PMID 38800710

Authors

Satoshi Yokoyama

Risa Kanai

Daisuke Fukao

Keigo Hamahata

Affiliations

Soon will be listed here.

Abstract

Pleuroparenchymal fibroelastosis (PPFE) is a rare, progressive, restrictive lung disease characterized by hypercarbic respiratory failure. In pediatrics, it has been described in patients with a history of malignancy who have received a bone marrow transplant, chemotherapy, or radiotherapy. It is characterized by pleural thickening, fibrosis, subpleural elastosis, and intraalveolar collagen deposits. Survival is poor, and the only therapy is lung transplantation. Here, we report a patient who developed PPFE as a late-onset pulmonary toxicity after treatment with anticancer chemotherapy for high-risk neuroblastoma (NB).

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