Association of Prealbumin with Short-term and Long-term Outcomes in Patients with Acute ST-segment Elevation Myocardial Infarction

Overview

Journal J Geriatr Cardiol

Specialty Geriatrics

Date 2024 May 27

PMID 38800549

Authors

Jing Tan

Jin Si

Ke-Ling Xiao

Ying-Hua Zhang

Qi Hua

Jing Li

Affiliations

Soon will be listed here.

Abstract

Background: Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction (STEMI) are available.

Methods: We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months (interquartile range: 26-73 months) follow-up period were compared between patients with the low prealbumin level (< 170 mg/L) and those with the high prealbumin level (≥ 170 mg/L).

Results: A total of 114 patients (4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class III (9.9% 4.4%, = 0.034), cardiovascular death (8.4% 3.4%, = 0.035) and the composite of major adverse cardiovascular events (19.2% 10.3%, = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level (< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events (odds ratio = 1.918, 95% CI: 1.250-2.942, = 0.003). The cut-off value of prealbumin level for predicting in-hospital death was 170 mg/L (area under the curve = 0.703, 95% CI: 0.651-0.754, < 0.001; sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level (170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent results.

Conclusions: Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently associated with an increased risk of long-term cardiovascular mortality in STEMI patients.

Citing Articles

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PMID: 39694533 PMC: 11656757. DOI: 10.1080/0886022X.2024.2441399.

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