A Rare Case Report of Breast Sarcoma and Synchronous Thymoma in a 60-year-old Woman

Overview

Journal Radiol Case Rep

Publisher Elsevier

Specialty Radiology

Date 2024 May 27

PMID 38800081

Authors

Marina Balbino

Federica Masino

Daniela Erriquez

Francesca Anna Carpagnano

Manuela Montatore

Giacomo Fascia

Alessio Sciacqua

Giuseppe Guglielmi

Affiliations

Soon will be listed here.

Abstract

This case report aims to describe the clinical presentation, imaging findings, histopathological features and therapeutic approach of a patient diagnosed with coexisting breast sarcoma and thymoma. A 64-year-old woman presented with a palpable lump in her left breast, and subsequent imaging studies (ultrasound, mammography, and MRI) revealed breast sarcoma, a rare and aggressive subtype of breast cancer. At the same time, the MRI revealed the presence of a thymoma. A multidisciplinary approach involving surgeon, breast specialist and oncologist is essential for optimal management and favorable outcomes in patients with this rare diagnosis.

References

Gaballah A, Jensen C, Palmquist S, Pickhardt P, Duran A, Broering G . Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol. 2017; 90(1075):20170039. PMC: 5594986. DOI: 10.1259/bjr.20170039. View

Duncan M, Lautner M . Sarcomas of the Breast. Surg Clin North Am. 2018; 98(4):869-876. DOI: 10.1016/j.suc.2018.03.013. View

Yin M, Mackley H, Drabick J, Harvey H . Primary female breast sarcoma: clinicopathological features, treatment and prognosis. Sci Rep. 2016; 6:31497. PMC: 4980597. DOI: 10.1038/srep31497. View

Bousquet G, Confavreux C, Magne N, Tunon de Lara C, Poortmans P, Senkus E . Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. Radiother Oncol. 2007; 85(3):355-61. DOI: 10.1016/j.radonc.2007.10.015. View

Silva B, Eulalio Filho W, Costa P, Silva R, Junior A, Chagas D . A rare case of primary breast angiosarcoma in a male: a case report. BMC Cancer. 2018; 18(1):978. PMC: 6192278. DOI: 10.1186/s12885-018-4895-3. View

Kaklamanos I, Birbas K, Syrigos K, Vlachodimitropoulos D, Goutas N, Bonatsos G . Breast angiosarcoma that is not related to radiation exposure: a comprehensive review of the literature. Surg Today. 2011; 41(2):163-8. DOI: 10.1007/s00595-010-4341-x. View

Adem C, Reynolds C, Ingle J, Nascimento A . Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. Br J Cancer. 2004; 91(2):237-41. PMC: 2409972. DOI: 10.1038/sj.bjc.6601920. View

Athanasiou E, Michalopoulou-Manoloutsiou E, Bobos M, Hatzibougias D, Zarogoulidis P, Katsikogiannis N . Coincidence of thymoma and breast cancer and in a 56-year-old female patient. Ann Transl Med. 2016; 4(22):446. PMC: 5159347. DOI: 10.21037/atm.2016.11.34. View

Zelek L, Llombart-Cussac A, Terrier P, Pivot X, Guinebretiere J, Le Pechoux C . Prognostic factors in primary breast sarcomas: a series of patients with long-term follow-up. J Clin Oncol. 2003; 21(13):2583-8. DOI: 10.1200/JCO.2003.06.080. View

10.

Sher T, Hennessy B, Valero V, Broglio K, Woodward W, Trent J . Primary angiosarcomas of the breast. Cancer. 2007; 110(1):173-8. PMC: 4329779. DOI: 10.1002/cncr.22784. View

11.

Bhosale S, Kshirsagar A, Patil M, Wader J, Nangare N, Patil P . Primary angiosarcoma of breast: A case report. Int J Surg Case Rep. 2013; 4(4):362-4. PMC: 3604700. DOI: 10.1016/j.ijscr.2013.01.016. View

12.

Wada M, Horinaka M, Yasuda S, Masuzawa M, Sakai T, Katoh N . PDK1 is a potential therapeutic target against angiosarcoma cells. J Dermatol Sci. 2015; 78(1):44-50. DOI: 10.1016/j.jdermsci.2015.01.015. View

13.

Radu I, Scripcariu V, Panuta A, Rusu A, Afrasanie V, Cojocaru E . Breast Sarcomas-How Different Are They from Breast Carcinomas? Clinical, Pathological, Imaging and Treatment Insights. Diagnostics (Basel). 2023; 13(8). PMC: 10137511. DOI: 10.3390/diagnostics13081370. View

14.

Chen S, Wu M, Wang J . Clinical implications of congenital interruption of inferior vena cava. J Formos Med Assoc. 2022; 121(10):1938-1944. DOI: 10.1016/j.jfma.2022.01.021. View

15.

Fury M, Antonescu C, Van Zee K, Brennan M, Maki R . A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J. 2005; 11(3):241-7. DOI: 10.1097/00130404-200505000-00011. View

16.

Yu L, Ke J, Du X, Yu Z, Gao D . Genetic characterization of thymoma. Sci Rep. 2019; 9(1):2369. PMC: 6382868. DOI: 10.1038/s41598-019-38878-z. View

17.

Kostic Peric J, Cirkovic A, Srzentic Drazilov S, Samardzic N, Skodric Trifunovic V, Jovanovic D . Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis. Radiol Oncol. 2023; 57(1):12-19. PMC: 10039471. DOI: 10.2478/raon-2023-0013. View