Noncoding RNAs: the Crucial Role of Programmed Cell Death in Osteoporosis

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2024 May 27

PMID 38799506

Authors

Juanjuan Han

Yuqing Zhu

Jiale Zhang

Leonid Kapilevich

Xin-An Zhang

Affiliations

Soon will be listed here.

Abstract

Osteoporosis is the most common skeletal disease characterized by an imbalance between bone resorption and bone remodeling. Osteoporosis can lead to bone loss and bone microstructural deterioration. This increases the risk of bone fragility and fracture, severely reducing patients' mobility and quality of life. However, the specific molecular mechanisms involved in the development of osteoporosis remain unclear. Increasing evidence suggests that multiple noncoding RNAs show differential expression in the osteoporosis state. Meanwhile, noncoding RNAs have been associated with an increased risk of osteoporosis and fracture. Noncoding RNAs are an important class of factors at the level of gene regulation and are mainly involved in cell proliferation, cell differentiation, and cell death. Programmed cell death is a genetically-regulated form of cell death involved in regulating the homeostasis of the internal environment. Noncoding RNA plays an important role in the programmed cell death process. The exploration of the noncoding RNA-programmed cell death axis has become an interesting area of research and has been shown to play a role in many diseases such as osteoporosis. In this review, we summarize the latest findings on the mechanism of noncoding RNA-mediated programmed cell death on bone homeostasis imbalance leading to osteoporosis. And we provide a deeper understanding of the role played by the noncoding RNA-programmed cell death axis at the gene regulatory level of osteoporosis. We hope to provide a unique opportunity to develop novel diagnostic and therapeutic approaches for osteoporosis.

References

Stockwell B, Friedmann Angeli J, Bayir H, Bush A, Conrad M, Dixon S . Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017; 171(2):273-285. PMC: 5685180. DOI: 10.1016/j.cell.2017.09.021. View

Guo M, Huang Y, Wu Q, Chai L, Jiang Z, Zeng Y . Chronic Ethanol Consumption Induces Osteopenia via Activation of Osteoblast Necroptosis. Oxid Med Cell Longev. 2021; 2021:3027954. PMC: 8566044. DOI: 10.1155/2021/3027954. View

Zhang B, Yuan P, Xu G, Chen Z, Li Z, Ye H . DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling. Cell Death Dis. 2021; 12(9):825. PMC: 8413376. DOI: 10.1038/s41419-021-04110-y. View

Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M . Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005; 17(3):393-403. DOI: 10.1016/j.molcel.2004.12.030. View

Huang W, Wu Y, Qiao M, Xie Z, Cen X, Huang X . CircRNA-miRNA networks in regulating bone disease. J Cell Physiol. 2021; 237(2):1225-1244. DOI: 10.1002/jcp.30625. View

Ruhl S, Shkarina K, Demarco B, Heilig R, Santos J, Broz P . ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation. Science. 2018; 362(6417):956-960. DOI: 10.1126/science.aar7607. View

Ozpak Akkus O, Atalay B . Post-menopausal osteoporosis: do body composition, nutritional habits, and physical activity affect bone mineral density?. Nutr Hosp. 2020; 37(5):977-983. DOI: 10.20960/nh.03214. View

Jilka R, Weinstein R, Parfitt A, Manolagas S . Quantifying osteoblast and osteocyte apoptosis: challenges and rewards. J Bone Miner Res. 2007; 22(10):1492-501. DOI: 10.1359/jbmr.070518. View

Peffers M, Chabronova A, Balaskas P, Fang Y, Dyer P, Cremers A . SnoRNA signatures in cartilage ageing and osteoarthritis. Sci Rep. 2020; 10(1):10641. PMC: 7326970. DOI: 10.1038/s41598-020-67446-z. View

10.

Hu Y, Zhang Y, Wang H, Ren R, Cui H, Huang W . miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson's disease. Cell Death Dis. 2019; 10(8):589. PMC: 6683159. DOI: 10.1038/s41419-019-1809-5. View

11.

Gao X, Liu C, Zhang Y, Wang Y, Zhou L, Li X . The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression. Cell Death Differ. 2021; 29(3):527-539. PMC: 8901615. DOI: 10.1038/s41418-021-00872-2. View

12.

Ashwal-Fluss R, Meyer M, Pamudurti N, Ivanov A, Bartok O, Hanan M . circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014; 56(1):55-66. DOI: 10.1016/j.molcel.2014.08.019. View

13.

Boatright K, Salvesen G . Mechanisms of caspase activation. Curr Opin Cell Biol. 2003; 15(6):725-31. DOI: 10.1016/j.ceb.2003.10.009. View

14.

Wang Y, Wei Z, Pan K, Li J, Chen Q . The function and mechanism of ferroptosis in cancer. Apoptosis. 2020; 25(11-12):786-798. DOI: 10.1007/s10495-020-01638-w. View

15.

Wang J, Cao B, Han D, Sun M, Feng J . Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy. Aging Dis. 2017; 8(1):71-84. PMC: 5287389. DOI: 10.14336/AD.2016.0530. View

16.

Chen G, Huang G, Lin H, Wu X, Tan X, Chen Z . MicroRNA-425-5p modulates osteoporosis by targeting annexin A2. Immun Ageing. 2021; 18(1):45. PMC: 8653595. DOI: 10.1186/s12979-021-00256-7. View

17.

Li X, Yang L, Guo Z . miR-193-3p ameliorates bone resorption in ovariectomized mice by blocking NFATc1 signaling. Int J Clin Exp Pathol. 2020; 12(11):4077-4086. PMC: 6949795. View

18.

Wang K, Liu F, Liu C, An T, Zhang J, Zhou L . The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873. Cell Death Differ. 2016; 23(8):1394-405. PMC: 4947670. DOI: 10.1038/cdd.2016.28. View

19.

Su F, Duan J, Zhu J, Fu H, Zheng X, Ge C . Long non‑coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation‑induced pyroptosis via microRNA‑448/gasdermin E in colorectal cancer cells. Int J Oncol. 2021; 59(4). PMC: 8448542. DOI: 10.3892/ijo.2021.5259. View

20.

Lu X, Zhang Y, Zheng Y, Chen B . The miRNA-15b/USP7/KDM6B axis engages in the initiation of osteoporosis by modulating osteoblast differentiation and autophagy. J Cell Mol Med. 2021; 25(4):2069-2081. PMC: 7882933. DOI: 10.1111/jcmm.16139. View