Extracellular Vesicles in Cancer: Golden Goose or Trojan Horse

Overview

Journal J Mol Cell Biol

Publisher Oxford University Press

Specialty Molecular Biology

Date 2024 May 26

PMID 38796692

Authors

Tao Han

Qian Hao

Tengfei Chao

Qinggang Sun

Yitian Chen

Bo Gao

Liping Guan

Wenjie Ren

Xiang Zhou

Affiliations

Soon will be listed here.

Abstract

Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines, cytokines, and growth factors. Extracellular vesicles (EVs) have emerged as important mediators of cell-to-cell and cell-to-environment communications. EVs from tumor cells, immune cells, and stromal cells can remodel the tumor microenvironment and promote cancer cell survival, proliferation, metastasis, immune evasion, and therapeutic resistance. Most importantly, EVs as natural nanoparticles can be manipulated to serve as a potent delivery system for targeted cancer therapy. EVs can be engineered or modified to improve their ability to target tumors and deliver therapeutic substances, such as chemotherapeutic drugs, nucleic acids, and proteins, for the treatment of cancer. This review provides an overview of the biogenesis and recycling of EVs, discusses their roles in cancer development, and highlights their potential as a delivery system for targeted cancer therapy.

Citing Articles

Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression.

Gan Y, Hao Q, Han T, Tong J, Yan Q, Zhong H Adv Sci (Weinh). 2024; 11(47):e2407370.

PMID: 39475053 PMC: 11653718. DOI: 10.1002/advs.202407370.

References

Liu J, Liu J, Qin G, Li J, Fu Z, Li J . MDSCs-derived GPR84 induces CD8 T-cell senescence via p53 activation to suppress the antitumor response. J Immunother Cancer. 2023; 11(11). PMC: 10685939. DOI: 10.1136/jitc-2023-007802. View

Eskelinen E, Illert A, Tanaka Y, Schwarzmann G, Blanz J, von Figura K . Role of LAMP-2 in lysosome biogenesis and autophagy. Mol Biol Cell. 2002; 13(9):3355-68. PMC: 124165. DOI: 10.1091/mbc.e02-02-0114. View

Du M, Gu J, Liu C, Liu N, Yu Z, Zhou C . Genome-wide CRISPR screen identified Rad18 as a determinant of doxorubicin sensitivity in osteosarcoma. J Exp Clin Cancer Res. 2022; 41(1):154. PMC: 9034549. DOI: 10.1186/s13046-022-02344-y. View

Macedo-Pereira A, Martins C, Lima J, Sarmento B . Digging the intercellular crosstalk via extracellular vesicles: May exosomes be the drug delivery solution for target glioblastoma?. J Control Release. 2023; 358:98-115. DOI: 10.1016/j.jconrel.2023.04.038. View

Jing X, Xie M, Ding K, Xu T, Fang Y, Ma P . Exosome-transmitted miR-769-5p confers cisplatin resistance and progression in gastric cancer by targeting CASP9 and promoting the ubiquitination degradation of p53. Clin Transl Med. 2022; 12(5):e780. PMC: 9076018. DOI: 10.1002/ctm2.780. View

Ruoslahti E . RGD and other recognition sequences for integrins. Annu Rev Cell Dev Biol. 1996; 12:697-715. DOI: 10.1146/annurev.cellbio.12.1.697. View

Couch Y, Buzas E, Di Vizio D, Gho Y, Harrison P, Hill A . A brief history of nearly EV-erything - The rise and rise of extracellular vesicles. J Extracell Vesicles. 2021; 10(14):e12144. PMC: 8681215. DOI: 10.1002/jev2.12144. View

Torralba D, Baixauli F, Villarroya-Beltri C, Fernandez-Delgado I, Latorre-Pellicer A, Acin-Perez R . Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018; 9(1):2658. PMC: 6037695. DOI: 10.1038/s41467-018-05077-9. View

Nail H, Chiu C, Leung C, Ahmed M, Wang H . Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments. J Biomed Sci. 2023; 30(1):69. PMC: 10440907. DOI: 10.1186/s12929-023-00964-w. View

10.

Friedrich M, Aigner A . Therapeutic siRNA: State-of-the-Art and Future Perspectives. BioDrugs. 2022; 36(5):549-571. PMC: 9396607. DOI: 10.1007/s40259-022-00549-3. View

11.

Dong X, Li C, Deng C, Liu J, Li D, Zhou T . Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment. Oncogene. 2023; 43(2):92-105. PMC: 10774126. DOI: 10.1038/s41388-023-02886-1. View

12.

Deng J, Ke H . Overcoming the resistance of hepatocellular carcinoma to PD-1/PD-L1 inhibitor and the resultant immunosuppression by CD38 siRNA-loaded extracellular vesicles. Oncoimmunology. 2023; 12(1):2152635. PMC: 9809939. DOI: 10.1080/2162402X.2022.2152635. View

13.

Jahn R, Scheller R . SNAREs--engines for membrane fusion. Nat Rev Mol Cell Biol. 2006; 7(9):631-43. DOI: 10.1038/nrm2002. View

14.

Jia G, Han Y, An Y, Ding Y, He C, Wang X . NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo. Biomaterials. 2018; 178:302-316. DOI: 10.1016/j.biomaterials.2018.06.029. View

15.

Mulcahy L, Pink R, Carter D . Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014; 3. PMC: 4122821. DOI: 10.3402/jev.v3.24641. View

16.

Rebelo R, Xavier C, Giovannetti E, Vasconcelos M . Fibroblasts in pancreatic cancer: molecular and clinical perspectives. Trends Mol Med. 2023; 29(6):439-453. DOI: 10.1016/j.molmed.2023.03.002. View

17.

Cooks T, Pateras I, Jenkins L, Patel K, Robles A, Morris J . Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246. Nat Commun. 2018; 9(1):771. PMC: 5823939. DOI: 10.1038/s41467-018-03224-w. View

18.

Hanahan D, Weinberg R . Hallmarks of cancer: the next generation. Cell. 2011; 144(5):646-74. DOI: 10.1016/j.cell.2011.02.013. View

19.

Bellavia D, Raimondo S, Calabrese G, Forte S, Cristaldi M, Patinella A . Interleukin 3- receptor targeted exosomes inhibit and Chronic Myelogenous Leukemia cell growth. Theranostics. 2017; 7(5):1333-1345. PMC: 5399597. DOI: 10.7150/thno.17092. View

20.

Popowski K, Moatti A, Scull G, Silkstone D, Lutz H, Lopez de Juan Abad B . Inhalable dry powder mRNA vaccines based on extracellular vesicles. Matter. 2022; 5(9):2960-2974. PMC: 9272513. DOI: 10.1016/j.matt.2022.06.012. View