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Bioavailability of Anthocyanins: Whole Foods Versus Extracts

Overview
Journal Nutrients
Date 2024 May 25
PMID 38794640
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Abstract

Anthocyanins have gained significant popularity in recent years for their diverse health benefits, yet their limited bioavailability poses a challenge. To address this concern, technologies have emerged to enhance anthocyanin concentration, often isolating these compounds from other food constituents. However, the extent to which isolated anthocyanins confer health benefits compared to their whole-food counterparts remains unclear. This review explores the current literature on anthocyanin bioavailability and metabolism in the body, with a focus on comparing bioavailability when consumed as extracts versus whole foods rich in anthocyanins, drawing from in vitro, in vivo, and human clinical studies. While direct comparisons between anthocyanin bioavailability in whole foods versus isolates are scarce, prevailing evidence favours whole-food consumption over anthocyanin extracts. Further clinical investigations, preferably with direct comparisons, are needed to validate these findings and elucidate the nuanced interplay between anthocyanins and food matrices, informing future research directions and practical recommendations.

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References
1.
Giordano L, Coletta W, Tamburrelli C, DImperio M, Crescente M, Silvestri C . Four-week ingestion of blood orange juice results in measurable anthocyanin urinary levels but does not affect cellular markers related to cardiovascular risk: a randomized cross-over study in healthy volunteers. Eur J Nutr. 2011; 51(5):541-8. DOI: 10.1007/s00394-011-0237-9. View

2.
Lila M, Burton-Freeman B, Grace M, Kalt W . Unraveling Anthocyanin Bioavailability for Human Health. Annu Rev Food Sci Technol. 2016; 7:375-93. DOI: 10.1146/annurev-food-041715-033346. View

3.
Majdoub Y, Ginestra G, Mandalari G, Dugo P, Mondello L, Cacciola F . The Digestibility of L. Polyphenols Using an In Vitro Human Digestion Model and Evaluation of Their Antimicrobial Activity. Nutrients. 2021; 13(7). PMC: 8308902. DOI: 10.3390/nu13072360. View

4.
Eskra J, Dodge A, Schlicht M, Bosland M . Effects of Black Raspberries and Their Constituents on Rat Prostate Carcinogenesis and Human Prostate Cancer Cell Growth In Vitro. Nutr Cancer. 2019; 72(4):672-685. PMC: 7012690. DOI: 10.1080/01635581.2019.1650943. View

5.
Wu Y, Han Y, Tao Y, Li D, Xie G, Show P . In vitro gastrointestinal digestion and fecal fermentation reveal the effect of different encapsulation materials on the release, degradation and modulation of gut microbiota of blueberry anthocyanin extract. Food Res Int. 2020; 132:109098. DOI: 10.1016/j.foodres.2020.109098. View