Integrin-Targeting Strategies for Adenovirus Gene Therapy

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2024 May 25

PMID 38793651

Authors

Glen R Nemerow

Affiliations

Soon will be listed here.

Abstract

Numerous human adenovirus (AdV) types are endowed with arginine-glycine-aspartic acid (RGD) sequences that enable them to recognize vitronectin-binding (αv) integrins. These RGD-binding cell receptors mediate AdV entry into host cells, a crucial early step in virus infection. Integrin interactions with adenoviruses not only initiate receptor-mediated endocytosis but also facilitate AdV capsid disassembly, a prerequisite for membrane penetration by AdV protein VI. This review discusses fundamental aspects of AdV-host interactions mediated by integrins. Recent efforts to re-engineer AdV vectors and non-viral nanoparticles to target αv integrins for bioimaging and the eradication of cancer cells will also be discussed.

Citing Articles

Strategies for Modifying Adenoviral Vectors for Gene Therapy.

Muravyeva A, Smirnikhina S Int J Mol Sci. 2024; 25(22).

PMID: 39596526 PMC: 11595218. DOI: 10.3390/ijms252212461.

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