Iris Pigmented Lesions and Risk of Cutaneous Melanoma: Case-Control Study in Lithuania

Overview

Journal J Pers Med

Date 2024 May 25

PMID 38793112

Authors

Lukas Semeklis

Laura Kapitanovaite

Grinvydas Butrimas

Kamilija Briede

Auguste Dubinskaite

Reda Zemaitiene

Skaidra Valiukeviciene

Affiliations

Soon will be listed here.

Abstract

The global incidence of cutaneous melanoma (CM) is rising, necessitating early detection and identification of risk factors across different populations. A case-control study with 180 patients with primary diagnosed CM and 182 healthy controls was conducted. Participants underwent ophthalmic and skin examinations, where the identification and counting of common melanocytic nevi (CMN) and atypical melanocytic nevi (AMN) was performed. During ophthalmic examination, high-resolution slit lamp iris images were taken. Images were categorized according to iris periphery, collaret, and freckles. There was no difference in iris periphery and collaret color between groups. However, blue/grey iris periphery and blue collaret with or without freckles were the most common patterns. The presence of pigmented iris lesions and 2-5 mm and ≥5 mm in diameter CMNs was strongly associated with CM risk. The evidence from this study indicates that blue or grey periphery and blue collaret iris pattern with iris freckles are 2.74 times higher in the CM group than controls. Further research is needed to explore iris patterns' association with CM risk in diverse populations.

Citing Articles

Cataract Prevalence in Patients with Cutaneous Melanoma in Lithuanian Population.

Semeklis L, Kapitanovaite L, Butrimas G, Briede K, Rackauskaite L, Zemaitiene R J Clin Med. 2024; 13(22).

PMID: 39597861 PMC: 11594909. DOI: 10.3390/jcm13226717.

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