Magnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2024 May 25

PMID 38792891

Authors

Mircea-Viorel Ciurea

Ioan Stefan Florian

Manuela Lenghel

Diana-Raluca Petea-Balea

Alexandra Roman

Silviu Albu

Affiliations

Soon will be listed here.

Abstract

: A magnetic resonance imaging (MRI) scan is part of the diagnostic protocol in pituitary adenoma patients. The goal of the present study is to present and analyse the MRI appearances of the sphenoid sinus (SS) in patients with non-functioning pituitary adenoma (NFPA). : This is a retrospective case-control study conducted between January 2015 and December 2023 in a tertiary referral hospital. Forty NFPA patients were included in the study group, while the control group consisted of 30 age- and gender-matched cases. : The sellar type of SS pneumatization was the most frequently encountered pattern among both groups. The presence of the lateral recess of the SS, mucosal cysts, and sphenoethmoidal cells was similar in both patient groups. The proportion of patients with SS mucosal thickness greater than 3 mm was 42.5% in NFPA group and 3% in the control group, and this difference was statistically significant ( < 0.001). The space between the two optic nerves was significantly larger in the NFPA group as compared to the control group ( < 0.001). : Our study was able to establish a statistically significant association between the presence of NFPA and both the thickening of the SS mucosa and increased space between optic nerves.

References

Chmielewski P . Clinical anatomy of the paranasal sinuses and its terminology. Anat Sci Int. 2023; 99(4):454-460. PMC: 11303572. DOI: 10.1007/s12565-023-00745-3. View

Lu Y, Pan J, Qi S, Shi J, Zhang X, Wu K . Pneumatization of the sphenoid sinus in Chinese: the differences from Caucasian and its application in the extended transsphenoidal approach. J Anat. 2011; 219(2):132-42. PMC: 3162234. DOI: 10.1111/j.1469-7580.2011.01380.x. View

Chong V, Fan Y . Comparison of CT and MRI features in sinusitis. Eur J Radiol. 1999; 29(1):47-54. DOI: 10.1016/s0720-048x(98)00019-9. View

Zada G, Agarwalla P, Mukundan Jr S, Dunn I, Golby A, Laws Jr E . The neurosurgical anatomy of the sphenoid sinus and sellar floor in endoscopic transsphenoidal surgery. J Neurosurg. 2011; 114(5):1319-30. PMC: 4131853. DOI: 10.3171/2010.11.JNS10768. View

HAMBERGER C, Hammer G, NORLEN G, Sjogren B . Transantrosphenoidal hypophysectomy. Arch Otolaryngol. 1961; 74:2-8. DOI: 10.1001/archotol.1961.00740030005002. View

Dal Secchi M, Dolci R, Teixeira R, Lazarini P . An Analysis of Anatomic Variations of the Sphenoid Sinus and Its Relationship to the Internal Carotid Artery. Int Arch Otorhinolaryngol. 2018; 22(2):161-166. PMC: 5882364. DOI: 10.1055/s-0037-1607336. View

Takasuna H, Sase T, Ito H, Ono H, Oshio K, Tanaka Y . Clinical significance of thickened sphenoid sinus mucosa in Rathke's cleft cyst. Surg Neurol Int. 2017; 8:263. PMC: 5682693. DOI: 10.4103/sni.sni_283_17. View

Liu J, Couldwell W . Pituitary apoplexy in the magnetic resonance imaging era: clinical significance of sphenoid sinus mucosal thickening. J Neurosurg. 2006; 104(6):892-8. DOI: 10.3171/jns.2006.104.6.892. View

Nazri M, Bux S, Tengku-Kamalden T, Ng K, Sun Z . Incidental detection of sinus mucosal abnormalities on CT and MRI imaging of the head. Quant Imaging Med Surg. 2013; 3(2):82-8. PMC: 3636478. DOI: 10.3978/j.issn.2223-4292.2013.03.06. View

10.

Ozdemir M, Kavak R . Season, Age and Sex-Related Differences in Incidental Magnetic Resonance Imaging Findings of Paranasal Sinuses in Adults. Turk Arch Otorhinolaryngol. 2019; 57(2):61-67. PMC: 6640665. DOI: 10.5152/tao.2019.4142. View

11.

Tarp B, Fiirgaard B, Christensen T, Jensen J, Black F . The prevalence and significance of incidental paranasal sinus abnormalities on MRI. Rhinology. 2000; 38(1):33-8. View

12.

Komatsu H, Matsumoto F, Kasai M, Kurano K, Sasaki D, Ikeda K . Cavernous sinus thrombosis caused by contralateral sphenoid sinusitis: a case report. Head Face Med. 2013; 9:9. PMC: 3605125. DOI: 10.1186/1746-160X-9-9. View

13.

Sharifi G, Dabbagh Ohadi M, Abedi M, Khajavi M, Shahjouei S, Moradi A . Surgical anatomic findings of sphenoid sinus in 1009 Iranian patients with pituitary adenoma undergoing endoscopic transsphenoidal surgery. Eur Arch Otorhinolaryngol. 2023; 280(6):2985-2991. DOI: 10.1007/s00405-022-07818-5. View

14.

Tomovic S, Esmaeili A, Chan N, Shukla P, Choudhry O, Liu J . High-resolution computed tomography analysis of variations of the sphenoid sinus. J Neurol Surg B Skull Base. 2014; 74(2):82-90. PMC: 3699211. DOI: 10.1055/s-0033-1333619. View

15.

Wang J, Bidari S, Inoue K, Yang H, Rhoton Jr A . Extensions of the sphenoid sinus: a new classification. Neurosurgery. 2010; 66(4):797-816. DOI: 10.1227/01.NEU.0000367619.24800.B1. View

16.

Ferrareze Nunes C, Cabral G, Mello Junior J, Lapenta M, Landeiro J . Pituitary macroadenoma: analysis of intercarotid artery distance compared to controls. Arq Neuropsiquiatr. 2016; 74(5):396-404. DOI: 10.1590/0004-282X20160046. View

17.

Ebner F, Kuerschner V, Dietz K, Bueltmann E, Naegele T, Honegger J . Reduced intercarotid artery distance in acromegaly: pathophysiologic considerations and implications for transsphenoidal surgery. Surg Neurol. 2009; 72(5):456-60. DOI: 10.1016/j.surneu.2009.07.006. View

18.

Wani M, Ruckenstein M, Parikh S . Magnetic resonance imaging of the paranasal sinuses: incidental abnormalities and their relationship to patient symptoms. J Otolaryngol. 2002; 30(5):257-62. DOI: 10.2310/7070.2001.19676. View

19.

Jeican I, Tudoran L, Florea A, Flonta M, Trombitas V, Apostol A . Chronic Rhinosinusitis: MALDI-TOF Mass Spectrometry Microbiological Diagnosis and Electron Microscopy Analysis; Experience of the 2nd Otorhinolaryngology Clinic of Cluj-Napoca, Romania. J Clin Med. 2020; 9(12). PMC: 7763976. DOI: 10.3390/jcm9123973. View

20.

Hansen A, Helvik A, Nordgard S, Bugten V, Stovner L, Haberg A . Incidental findings in MRI of the paranasal sinuses in adults: a population-based study (HUNT MRI). BMC Ear Nose Throat Disord. 2015; 14(1):13. PMC: 4324827. DOI: 10.1186/1472-6815-14-13. View