Selenoprotein P-1 (SEPP1) As an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass

Overview

Journal J Clin Med

Specialty General Medicine

Date 2024 May 25

PMID 38792487

Authors

Giuseppe Filiberto Serraino

Davide Bolignano

Federica Jiritano

Giuseppe Coppolino

Desiree Napolitano

Mariateresa Zicarelli

Patrizia Pizzini

Sebastiano Cutrupi

Alessandra Testa

Belinda Spoto

Michele Andreucci

Pasquale Mastroroberto

Raffaele Serra

Affiliations

Soon will be listed here.

Abstract

: Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery. : Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3) : circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598, < 0.0001) and at 72 h (R = 0.308, = 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532, < 0.0001), 48 h (R = 0.348, = 0.01) and 72 h (R = 0.377, = 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389, = 0.008) and cross-clamp time (R = 0.374, = 0.001); (4) : Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury.

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