AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 May 25

PMID 38791343

Authors

Agnieszka Pozarska

Krzysztof Karpiesiuk

Wojciech Kozera

Urszula Czarnik

Michal Dabrowski

Lukasz Zielonka

Affiliations

Soon will be listed here.

Abstract

Aims: The current review aims to outline and summarize the latest research on aflatoxin, with research studies describing natural, herbal and chemical compound applications in animal (pig) models and in vitro cellular studies. Aflatoxin, a carcinogenic toxin metabolite, is produced by in humid environments, posing a threat to human health and crop production. The current treatment involves the prevention of exposure to aflatoxin and counteracting its harmful toxic effects, enabling survival and research studies on an antidote for aflatoxin.

Objectives: To summarize current research prospects and to outline the influence of aflatoxin on animal forage in farm production, food and crop processing. The research application of remedies to treat aflatoxin is undergoing development to pinpoint biochemical pathways responsible for aflatoxin effects transmission and actions of treatment.

Significance: To underline the environmental stress of aflatoxin on meat and dairy products; to describe clinical syndromes associated with aflatoxicosis on human health that are counteracted with proposed treatment and preventive interventions. To understand how to improve the health of farm animals with feed conditions.

Citing Articles

The Role of AFB1, OTA, TCNs, and Patulin in Forensic Sciences: Applications in Autopsy, Criminal Investigations, and Public Health Prevention.

Sacco M, Gualtieri S, Tarallo A, Verrina M, Carbone A, Mazzuca W Toxins (Basel). 2024; 16(12.

PMID: 39728772 PMC: 11728568. DOI: 10.3390/toxins16120514.

Bacillus CotA laccase improved the intestinal health, amino acid metabolism and hepatic metabolic capacity of Pekin ducks fed naturally contaminated AFB diet.

Ma M, Wang Q, Liu Y, Li G, Liu L, Wang G J Anim Sci Biotechnol. 2024; 15(1):138.

PMID: 39385285 PMC: 11465776. DOI: 10.1186/s40104-024-01091-8.

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