Towards More Reliable Non-linear Mendelian Randomization Investigations

Overview

Journal Eur J Epidemiol

Specialty Public Health

Date 2024 May 24

PMID 38789825

Authors

Stephen Burgess

Affiliations

Soon will be listed here.

Citing Articles

Identification of effect modifiers using a stratified Mendelian randomization algorithmic framework.

Man A, Knusel L, Graf J, Lali R, Le A, Di Scipio M Eur J Epidemiol. 2025; .

PMID: 40072671 DOI: 10.1007/s10654-025-01213-0.

A Review of Mendelian Randomization: Assumptions, Methods, and Application to Obesity-Related Diseases.

Lee S, Lee W J Obes Metab Syndr. 2025; 34(1):14-26.

PMID: 39809435 PMC: 11799604. DOI: 10.7570/jomes24031.

Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.

Daghlas I, Gill D J Cereb Blood Flow Metab. 2024; :271678X241305916.

PMID: 39628323 PMC: 11615907. DOI: 10.1177/0271678X241305916.

Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses.

Bassett E, Gjekmarkaj E, Mason A, Zhao S, Burgess S Transl Psychiatry. 2024; 14(1):274.

PMID: 38965219 PMC: 11224391. DOI: 10.1038/s41398-024-02997-7.

Cardiovascular disease risk factors and infertility: multivariable analyses and one-sample Mendelian randomization analyses in the Trøndelag Health Study.

Skara K, Hernaez A, Naess O, Fraser A, Lawlor D, Burgess S Hum Reprod Open. 2024; 2024(3):hoae033.

PMID: 38911051 PMC: 11190059. DOI: 10.1093/hropen/hoae033.

References

Burgess S, Davies N, Thompson S . Instrumental variable analysis with a nonlinear exposure-outcome relationship. Epidemiology. 2014; 25(6):877-85. PMC: 4222800. DOI: 10.1097/EDE.0000000000000161. View

. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses. Lancet Diabetes Endocrinol. 2023; 12(1):e2-e11. PMC: 7615586. DOI: 10.1016/S2213-8587(23)00287-5. View

Lawlor D, Tilling K, Davey Smith G . Triangulation in aetiological epidemiology. Int J Epidemiol. 2017; 45(6):1866-1886. PMC: 5841843. DOI: 10.1093/ije/dyw314. View

Burgess S, Sun Y, Zhou A, Buck C, Mason A, Mai X . Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analyses. BMJ Open. 2024; 14(5):e081399. PMC: 11097829. DOI: 10.1136/bmjopen-2023-081399. View

Schoeler T, Speed D, Porcu E, Pirastu N, Pingault J, Kutalik Z . Participation bias in the UK Biobank distorts genetic associations and downstream analyses. Nat Hum Behav. 2023; 7(7):1216-1227. PMC: 10365993. DOI: 10.1038/s41562-023-01579-9. View

Tian H, Mason A, Liu C, Burgess S . Relaxing parametric assumptions for non-linear Mendelian randomization using a doubly-ranked stratification method. PLoS Genet. 2023; 19(6):e1010823. PMC: 10343089. DOI: 10.1371/journal.pgen.1010823. View

Burgess S, Thompson S . Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011; 40(3):755-64. DOI: 10.1093/ije/dyr036. View

Cole S, Platt R, Schisterman E, Chu H, Westreich D, Richardson D . Illustrating bias due to conditioning on a collider. Int J Epidemiol. 2009; 39(2):417-20. PMC: 2846442. DOI: 10.1093/ije/dyp334. View

Hamilton F, Hughes D, Spiller W, Tilling K, Davey Smith G . Non-linear Mendelian randomization: detection of biases using negative controls with a focus on BMI, Vitamin D and LDL cholesterol. Eur J Epidemiol. 2024; 39(5):451-465. PMC: 11219394. DOI: 10.1007/s10654-024-01113-9. View

10.

Fry A, Littlejohns T, Sudlow C, Doherty N, Adamska L, Sprosen T . Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population. Am J Epidemiol. 2017; 186(9):1026-1034. PMC: 5860371. DOI: 10.1093/aje/kwx246. View

11.

Burgess S, Davey Smith G, Davies N, Dudbridge F, Gill D, Glymour M . Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Res. 2023; 4:186. PMC: 7384151. DOI: 10.12688/wellcomeopenres.15555.3. View

12.

Burgess S . Violation of the Constant Genetic Effect Assumption Can Result in Biased Estimates for Non-Linear Mendelian Randomization. Hum Hered. 2023; 88(1):79-90. PMC: 10614256. DOI: 10.1159/000531659. View

13.

Manson J, Cook N, Lee I, Christen W, Bassuk S, Mora S . Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med. 2018; 380(1):33-44. PMC: 6425757. DOI: 10.1056/NEJMoa1809944. View

14.

Yusuf S, Wittes J, Probstfield J, Tyroler H . Analysis and interpretation of treatment effects in subgroups of patients in randomized clinical trials. JAMA. 1991; 266(1):93-8. View

15.

Staley J, Burgess S . Semiparametric methods for estimation of a nonlinear exposure-outcome relationship using instrumental variables with application to Mendelian randomization. Genet Epidemiol. 2017; 41(4):341-352. PMC: 5400068. DOI: 10.1002/gepi.22041. View

16.

Yang G, Mason A, Wood A, Schooling C, Burgess S . Dose-Response Associations of Lipid Traits With Coronary Artery Disease and Mortality. JAMA Netw Open. 2024; 7(1):e2352572. PMC: 10799266. DOI: 10.1001/jamanetworkopen.2023.52572. View