Comparative Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and Seven Other Antimicrobial Agents Tested Against Bovine Isolates of and

Overview

Journal Pathogens

Date 2024 May 24

PMID 38787251

Authors

Joseph M Blondeau

Shantelle D Fitch

Affiliations

Soon will be listed here.

Abstract

Pradofloxacin-a dual-targeting fluoroquinolone-is the most recent approved for use in food animals. Minimum inhibitory and mutant prevention concentration values were determined for pradofloxacin, ceftiofur, enrofloxacin, florfenicol, marbofloxacin, tildipirosin, tilmicosin, and tulathromycin. For strains, MIC values were ≤0.016/≤0.016/≤0.016 and MPC values were 0.031/0.063/0.063; for strains, the MIC values ≤0.016/≤0.016/0.031 and MPC ≤ 0.016/0.031/0.063 for pradofloxacin. The pradofloxacin C/MIC and C/MPC values for and strains, respectively, were 212.5 and 53.9 and 212.5 and 109.7. Similarly, AUC/MIC and AUC/MPC for were 825 and 209.5, and for they were 825 and 425.8. Pradofloxacin would exceed the mutant selection window for >12-16 h. Pradofloxacin appears to have a low likelihood for resistance selection against key bovine respiratory disease bacterial pathogens based on low MIC and MPC values.

Citing Articles

Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica.

Foster D, Halleran J, Jacob M, Hempstead S, Borst L, Negrao Watanabe T J Vet Intern Med. 2024; 39(1):e17270.

PMID: 39655779 PMC: 11629255. DOI: 10.1111/jvim.17270.

References

Zhang L, Xie H, Wang Y, Wang H, Hu J, Zhang G . Pharmacodynamic Parameters of Pharmacokinetic/Pharmacodynamic (PK/PD) Integration Models. Front Vet Sci. 2022; 9:860472. PMC: 8989418. DOI: 10.3389/fvets.2022.860472. View

Menge M, Rose M, Bohland C, Zschiesche E, Kilp S, Metz W . Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). J Vet Pharmacol Ther. 2011; 35(6):550-9. DOI: 10.1111/j.1365-2885.2011.01349.x. View

Bretzlaff K, Ott R, Koritz G, Gustafsson B, Davis L . Florfenicol in non-lactating dairy cows: pharmacokinetics, binding to plasma proteins, and effects on phagocytosis by blood neutrophils. J Vet Pharmacol Ther. 1987; 10(3):233-40. DOI: 10.1111/j.1365-2885.1987.tb00534.x. View

Kasimanickam V, Kasimanickam M, Kasimanickam R . Antibiotics Use in Food Animal Production: Escalation of Antimicrobial Resistance: Where Are We Now in Combating AMR?. Med Sci (Basel). 2021; 9(1). PMC: 7931007. DOI: 10.3390/medsci9010014. View

Modric S, Webb A, Davidson M . Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats. Lab Anim Sci. 1999; 49(3):248-53. View

Wetzstein H . Comparative mutant prevention concentrations of pradofloxacin and other veterinary fluoroquinolones indicate differing potentials in preventing selection of resistance. Antimicrob Agents Chemother. 2005; 49(10):4166-73. PMC: 1251556. DOI: 10.1128/AAC.49.10.4166-4173.2005. View

Bingen E, Lambert-Zechovsky N, Leclercq R, Doit C, Mariani-Kurkdjian P . Bactericidal activity of vancomycin, daptomycin, ampicillin and aminoglycosides against vancomycin-resistant Enterococcus faecium. J Antimicrob Chemother. 1990; 26(5):619-26. DOI: 10.1093/jac/26.5.619. View

Booker C, Lubbers B . Bovine Respiratory Disease Treatment Failure: Impact and Potential Causes. Vet Clin North Am Food Anim Pract. 2020; 36(2):487-496. DOI: 10.1016/j.cvfa.2020.03.007. View

Gaudino M, Nagamine B, Ducatez M, Meyer G . Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence. Vet Res. 2022; 53(1):70. PMC: 9449274. DOI: 10.1186/s13567-022-01086-1. View

10.

FRISCH A, Tripp J, Barrett C, Pidgeon B . THE SPECIFIC POLYSACCHARIDE CONTENT OF PNEUMONIC LUNGS. J Exp Med. 2009; 76(6):505-10. PMC: 2135280. DOI: 10.1084/jem.76.6.505. View

11.

Cui J, Liu Y, Wang R, Tong W, Drlica K, Zhao X . The mutant selection window in rabbits infected with Staphylococcus aureus. J Infect Dis. 2006; 194(11):1601-8. DOI: 10.1086/508752. View

12.

Dagan R, Klugman K, Craig W, Baquero F . Evidence to support the rationale that bacterial eradication in respiratory tract infection is an important aim of antimicrobial therapy. J Antimicrob Chemother. 2001; 47(2):129-40. DOI: 10.1093/jac/47.2.129. View

13.

Hartmann A, Helps C, Lappin M, Werckenthin C, Hartmann K . Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections. J Vet Intern Med. 2008; 22(1):44-52. DOI: 10.1111/j.1939-1676.2007.0012.x. View

14.

Dowers K, Tasker S, Radecki S, Lappin M . Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats. Am J Vet Res. 2009; 70(1):105-11. DOI: 10.2460/ajvr.70.1.105. View

15.

Blondeau J, Zhao X, Hansen G, Drlica K . Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae. Antimicrob Agents Chemother. 2001; 45(2):433-8. PMC: 90309. DOI: 10.1128/AAC.45.2.433-438.2001. View

16.

Belew S, Kim J, Hossain M, Park J, Lee S, Park Y . Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration in Hanwoo, Korean native cattle. J Vet Med Sci. 2014; 77(3):327-9. PMC: 4383779. DOI: 10.1292/jvms.14-0221. View

17.

Lees P . Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat. J Vet Pharmacol Ther. 2013; 36(3):209-21. DOI: 10.1111/jvp.12036. View

18.

Blondeau J . New concepts in antimicrobial susceptibility testing: the mutant prevention concentration and mutant selection window approach. Vet Dermatol. 2010; 20(5-6):383-96. DOI: 10.1111/j.1365-3164.2009.00856.x. View

19.

Callan R, Garry F . Biosecurity and bovine respiratory disease. Vet Clin North Am Food Anim Pract. 2002; 18(1):57-77. PMC: 7126375. DOI: 10.1016/s0749-0720(02)00004-x. View

20.

Vilalta C, Giboin H, Schneider M, El Garch F, Fraile L . Pharmacokinetic/pharmacodynamic evaluation of marbofloxacin in the treatment of Haemophilus parasuis and Actinobacillus pleuropneumoniae infections in nursery and fattener pigs using Monte Carlo simulations. J Vet Pharmacol Ther. 2014; 37(6):542-9. DOI: 10.1111/jvp.12134. View