High-Risk Areas for Congenital Zika Syndrome in Rio De Janeiro: Spatial Cluster Detection

Overview

Journal Trop Med Infect Dis

Specialty Infectious Diseases

Date 2024 May 24

PMID 38787038

Authors

Danielle Amaral de Freitas

Mayumi Duarte Wakimoto

Sonia Dias

Reinaldo Souza-Santos

Affiliations

Soon will be listed here.

Abstract

Brazil reported 18,282 suspected congenital Zika syndrome (CZS) cases up to 2018 and accounts for 61.4% of the total reported Zika cases in the Americas in the period. To detect high-risk areas for children with CZS in the city of Rio de Janeiro, we used cluster detection and thematic maps. We analyzed data using a Poisson model in Satscan 10.1.3 software. We also analyzed the records of children with CZS from 2015 to 2016 to describe the clinical and epidemiological maternal and child profile, as well as live births in 2016 and the social development index (SDI) by neighborhood. In 2015 and 2016, the incidence rates of CZS were 8.84 and 46.96 per 100,000 live births in the city, respectively. Severe congenital findings such as microcephaly and brain damage, osteoarticular impairment, ocular abnormalities, and hearing loss were observed in 47 children. The spatial distribution of CZS was concentrated in the north and west zones in heterogeneous neighborhoods. The neighborhoods with the highest occurrence of CZS cases were found to have the worst SDIs. Stascan detected three spatial clusters in the north zone, where the SDI is lower. The clusters presented high relative risks for CZS (7.86, 1.46, and 2.08), although they were not statistically significant. Our findings highlight a higher occurrence of CZS in areas with less favorable socioeconomic conditions.

References

Souza W, de Albuquerque M, Vazquez E, Bezerra L, Mendes A, Lyra T . Microcephaly epidemic related to the Zika virus and living conditions in Recife, Northeast Brazil. BMC Public Health. 2018; 18(1):130. PMC: 5767029. DOI: 10.1186/s12889-018-5039-z. View

Van der Linden V, Junior H, Leal M, Rolim Filho E, van der Linden A, de Fatima Viana Vasco Aragao M . Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies. Arq Neuropsiquiatr. 2017; 75(6):381-386. DOI: 10.1590/0004-282X20170066. View

Mussi-Pinhata M, Yamamoto A . [Congenital and perinatal infections]. J Pediatr (Rio J). 2003; 75 Suppl 1:S15-30. DOI: 10.2223/jped.368. View

Aragao M, Van der Linden V, Brainer-Lima A, Coeli R, Rocha M, Sobral da Silva P . Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study. BMJ. 2016; 353:i1901. PMC: 4830901. DOI: 10.1136/bmj.i1901. View

Cofre F, Delpiano L, Labrana Y, Reyes A, Sandoval A, Izquierdo G . [TORCH syndrome: Rational approach of pre and post natal diagnosis and treatment. Recommendations of the Advisory Committee on Neonatal Infections Sociedad Chilena de Infectología, 2016]. Rev Chilena Infectol. 2016; 33(2):191-216. DOI: 10.4067/S0716-10182016000200010. View

Perez S, Tato R, Cabrera J, Lopez A, Robles O, Paz E . Confirmed case of Zika virus congenital infection, Spain, March 2016. Euro Surveill. 2016; 21(24). DOI: 10.2807/1560-7917.ES.2016.21.24.30261. View

Marinho F, Araujo V, Porto D, Ferreira H, Coelho M, Lecca R . Microcephaly in Brazil: prevalence and characterization of cases from the Information System on Live Births (Sinasc), 2000-2015. Epidemiol Serv Saude. 2016; 25(4):701-712. DOI: 10.5123/S1679-49742016000400004. View

Mattos A, Rastely-Junior V, Pires M, Aguilar J, Lessa M, Regis C . Predictors of Neurodevelopment in Microcephaly Associated with Congenital Zika Syndrome: A Prospective Study. Children (Basel). 2023; 10(12). PMC: 10741834. DOI: 10.3390/children10121831. View

Akter R, Naish S, Gatton M, Bambrick H, Hu W, Tong S . Spatial and temporal analysis of dengue infections in Queensland, Australia: Recent trend and perspectives. PLoS One. 2019; 14(7):e0220134. PMC: 6645541. DOI: 10.1371/journal.pone.0220134. View

10.

Mocelin H, Catao R, Freitas P, Prado T, Bertolde A, Castro M . Analysis of the spatial distribution of cases of Zika virus infection and congenital Zika virus syndrome in a state in the southeastern region of Brazil: Sociodemographic factors and implications for public health. Int J Gynaecol Obstet. 2020; 148 Suppl 2:61-69. PMC: 7065179. DOI: 10.1002/ijgo.13049. View

11.

Musso D, Nilles E, Cao-Lormeau V . Rapid spread of emerging Zika virus in the Pacific area. Clin Microbiol Infect. 2014; 20(10):O595-6. DOI: 10.1111/1469-0691.12707. View

12.

Oliveira F, Silva A, Hora S, de Oliveira S, Silva Junior A, Cardoso C . Healthcare for children with congenital Zika syndrome: analysis of access to social rights. Cien Saude Colet. 2022; 27(9):3679-3688. DOI: 10.1590/1413-81232022279.02972022. View

13.

de Melo A, Lyra T, Barbosa J, Araujo T . Congenital zika syndrome and family impacts: an integrative review. Cien Saude Colet. 2023; 28(5):1425-1441. DOI: 10.1590/1413-81232023285.14852022. View

14.

Mendes A, Campos D, Silva L, Lopes Moreira M, Arruda L . Facing a new reality from the Zika Virus Congenital Syndrome: the families' perspective. Cien Saude Colet. 2020; 25(10):3785-3794. DOI: 10.1590/1413-812320202510.00962019. View

15.

Moron A, Cavalheiro S, Milani H, Sarmento S, Tanuri C, de Souza F . Microcephaly associated with maternal Zika virus infection. BJOG. 2016; 123(8):1265-1269. DOI: 10.1111/1471-0528.14072. View

16.

Braga J, Bressan C, Dalvi A, Amaral Calvet G, Daumas R, Rodrigues N . Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics. PLoS One. 2017; 12(6):e0179725. PMC: 5484469. DOI: 10.1371/journal.pone.0179725. View

17.

Shuaib W, Stanazai H, Abazid A, Mattar A . Re-Emergence of Zika Virus: A Review on Pathogenesis, Clinical Manifestations, Diagnosis, Treatment, and Prevention. Am J Med. 2016; 129(8):879.e7-879.e12. DOI: 10.1016/j.amjmed.2016.02.027. View

18.

Santos J, Honorio N, Nobre A . Definition of persistent areas with increased dengue risk by detecting clusters in populations with differing mobility and immunity in Rio de Janeiro, Brazil. Cad Saude Publica. 2019; 35(12):e00248118. DOI: 10.1590/0102-311X00248118. View

19.

Freitas B, de Oliveira Dias J, Prazeres J, Sacramento G, Ko A, Maia M . Ocular Findings in Infants With Microcephaly Associated With Presumed Zika Virus Congenital Infection in Salvador, Brazil. JAMA Ophthalmol. 2016; 134(5):529-535. PMC: 5444996. DOI: 10.1001/jamaophthalmol.2016.0267. View

20.

Faria N, da Silva Azevedo R, Kraemer M, Souza R, Cunha M, Hill S . Zika virus in the Americas: Early epidemiological and genetic findings. Science. 2016; 352(6283):345-349. PMC: 4918795. DOI: 10.1126/science.aaf5036. View