The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Overview

Journal Biomimetics (Basel)

Date 2024 May 24

PMID 38786505

Authors

Mauro Pollini

Federica Paladini

Affiliations

Soon will be listed here.

Abstract

In order to reduce the toxicological impact on healthy cells and to improve the therapeutic response, many drug delivery systems have been fabricated and analysed, involving the use of different natural and synthetic materials at macro-, micro- and nanoscales. Among the natural materials which have demonstrated a huge potential for the development of effective drug delivery systems, silk fibroin has emerged for its excellent biological properties and for the possibility to be processed in a wide range of forms, which can be compliant with multiple active molecules and pharmaceutical ingredients for the treatment of various diseases. This review aims at presenting silk fibroin as an interesting biopolymer for applications in drug delivery systems, exploring the results obtained in recent works in terms of technological progress and effectiveness in vitro and in vivo.

Citing Articles

Microparticles Made with Silk Proteins for Melanoma Adjuvant Therapy.

Trombino S, Sole R, Curcio F, Malivindi R, Caracciolo D, Mellace S Gels. 2024; 10(8).

PMID: 39195014 PMC: 11353667. DOI: 10.3390/gels10080485.

References

Zheng H, Zuo B . Functional silk fibroin hydrogels: preparation, properties and applications. J Mater Chem B. 2021; 9(5):1238-1258. DOI: 10.1039/d0tb02099k. View

Huang L, Chen L, Chen H, Wang M, Jin L, Zhou S . Biomimetic Scaffolds for Tendon Tissue Regeneration. Biomimetics (Basel). 2023; 8(2). PMC: 10296678. DOI: 10.3390/biomimetics8020246. View

Donnelly R, Prausnitz M . The promise of microneedle technologies for drug delivery. Drug Deliv Transl Res. 2023; 14(3):573-580. DOI: 10.1007/s13346-023-01430-8. View

Pham D, Tiyaboonchai W . Fibroin nanoparticles: a promising drug delivery system. Drug Deliv. 2020; 27(1):431-448. PMC: 7144220. DOI: 10.1080/10717544.2020.1736208. View

Jeencham R, Sutheerawattananonda M, Rungchang S, Tiyaboonchai W . Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium. Drug Deliv. 2020; 27(1):782-790. PMC: 7269043. DOI: 10.1080/10717544.2020.1765432. View

Panico A, Paladini F, Pollini M . Development of regenerative and flexible fibroin-based wound dressings. J Biomed Mater Res B Appl Biomater. 2018; 107(1):7-18. DOI: 10.1002/jbm.b.34090. View

Wani S, Zargar M, Masoodi M, Alshehri S, Alam P, Ghoneim M . Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing. Int J Mol Sci. 2022; 23(22). PMC: 9692988. DOI: 10.3390/ijms232214421. View

Nguyen T, Nguyen Q, Nguyen V, Le T, Huynh V, Vo D . Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review. Polymers (Basel). 2019; 11(12). PMC: 6960760. DOI: 10.3390/polym11121933. View

Lin Z, Zheng K, Zhong J, Zheng X . Advances in microneedle-based therapy for bone disorders. Biomed Pharmacother. 2023; 165:115013. DOI: 10.1016/j.biopha.2023.115013. View

10.

Yang D, Chen M, Sun Y, Jin Y, Lu C, Pan X . Microneedle-mediated transdermal drug delivery for treating diverse skin diseases. Acta Biomater. 2020; 121:119-133. DOI: 10.1016/j.actbio.2020.12.004. View

11.

Hmingthansanga V, Singh N, Banerjee S, Manickam S, Velayutham R, Natesan S . Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches. Pharmaceutics. 2022; 14(12). PMC: 9785322. DOI: 10.3390/pharmaceutics14122818. View

12.

Varanko A, Saha S, Chilkoti A . Recent trends in protein and peptide-based biomaterials for advanced drug delivery. Adv Drug Deliv Rev. 2020; 156:133-187. PMC: 7456198. DOI: 10.1016/j.addr.2020.08.008. View

13.

Madappura A, Madduri S . A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine. Comput Struct Biotechnol J. 2023; 21:4868-4886. PMC: 10583100. DOI: 10.1016/j.csbj.2023.10.012. View

14.

Pollini M, Paladini F . Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin. Materials (Basel). 2020; 13(15). PMC: 7436046. DOI: 10.3390/ma13153361. View

15.

Dorishetty P, Dutta N, Choudhury N . Silk fibroins in multiscale dimensions for diverse applications. RSC Adv. 2022; 10(55):33227-33247. PMC: 9056751. DOI: 10.1039/d0ra03964k. View

16.

Park K . Controlled drug delivery systems: past forward and future back. J Control Release. 2014; 190:3-8. PMC: 4142099. DOI: 10.1016/j.jconrel.2014.03.054. View

17.

Adepu S, Ramakrishna S . Controlled Drug Delivery Systems: Current Status and Future Directions. Molecules. 2021; 26(19). PMC: 8512302. DOI: 10.3390/molecules26195905. View

18.

Liu J, Sun H, Peng Y, Chen L, Xu W, Shao R . Preparation and Characterization of Natural Silk Fibroin Hydrogel for Protein Drug Delivery. Molecules. 2022; 27(11). PMC: 9181960. DOI: 10.3390/molecules27113418. View

19.

Sakunpongpitiporn P, Naeowong W, Sirivat A . Enhanced transdermal insulin basal release from silk fibroin (SF) hydrogels via iontophoresis. Drug Deliv. 2022; 29(1):2234-2244. PMC: 9848418. DOI: 10.1080/10717544.2022.2096717. View

20.

Park K . Drug delivery of the future: Chasing the invisible gorilla. J Control Release. 2015; 240:2-8. PMC: 4848181. DOI: 10.1016/j.jconrel.2015.10.048. View