Bone and Extracellular Signal-Related Kinase 5 (ERK5)

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2024 May 24

PMID 38785963

Authors

Lei Wen

Zirui Liu

Libo Zhou

Zhongcheng Liu

Qingda Li

Bin Geng

Yayi Xia

Affiliations

Soon will be listed here.

Abstract

Bones are vital for anchoring muscles, tendons, and ligaments, serving as a fundamental element of the human skeletal structure. However, our understanding of bone development mechanisms and the maintenance of bone homeostasis is still limited. Extracellular signal-related kinase 5 (ERK5), a recently identified member of the mitogen-activated protein kinase (MAPK) family, plays a critical role in the pathogenesis and progression of various diseases, especially neoplasms. Recent studies have highlighted ERK5's significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health. It also examines therapeutic strategies and future research avenues targeting ERK5.

References

Zhang J, Pearson A, Sabherwal N, Telfer B, Ali N, Kan K . Inhibiting ERK5 overcomes breast cancer resistance to anti-HER2 therapy by targeting the G1/S cell cycle transition. Cancer Res Commun. 2022; 2(3):131-145. PMC: 7613885. DOI: 10.1158/2767-9764.CRC-21-0089. View

Suzaki Y, Yoshizumi M, Kagami S, Koyama A, Taketani Y, Houchi H . Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J Biol Chem. 2002; 277(11):9614-21. DOI: 10.1074/jbc.M111790200. View

Nagai T, Urushihara M, Kinoshita Y, Jamba A, Kondo S, Kagami S . Differential regulation of angiotensin II-induced extracellular signal regulated kinase-1/2 and -5 in progressive glomerulonephritis. Nephrology (Carlton). 2015; 21(11):950-958. DOI: 10.1111/nep.12685. View

Ortiz-Ruiz M, Alvarez-Fernandez S, Parrott T, Zaknoen S, Burrows F, Ocana A . Therapeutic potential of ERK5 targeting in triple negative breast cancer. Oncotarget. 2014; 5(22):11308-18. PMC: 4294347. DOI: 10.18632/oncotarget.2324. View

Hartmann J, Brauer-Hartmann D, Kardosova M, Wurm A, Wilke F, Schodel C . MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia. Cell Death Dis. 2018; 9(8):814. PMC: 6062564. DOI: 10.1038/s41419-018-0837-x. View

Rolvien T, Amling M . Disuse Osteoporosis: Clinical and Mechanistic Insights. Calcif Tissue Int. 2021; 110(5):592-604. PMC: 9013332. DOI: 10.1007/s00223-021-00836-1. View

Vanchin B, Offringa E, Friedrich J, Brinker M, Kiers B, Pereira A . MicroRNA-374b induces endothelial-to-mesenchymal transition and early lesion formation through the inhibition of MAPK7 signaling. J Pathol. 2018; 247(4):456-470. PMC: 6590197. DOI: 10.1002/path.5204. View

Sawhney R, Liu W, Brattain M . A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling. J Cell Physiol. 2008; 219(1):152-61. PMC: 7064882. DOI: 10.1002/jcp.21662. View

Nguyen D, Lemos C, Wortmann L, Eis K, Holton S, Boemer U . Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2018; 62(2):928-940. DOI: 10.1021/acs.jmedchem.8b01606. View

10.

Lu L, Chen J, Tang H, Bai L, Lu C, Wang K . EGCG Suppresses ERK5 Activation to Reverse Tobacco Smoke-Triggered Gastric Epithelial-Mesenchymal Transition in BALB/c Mice. Nutrients. 2016; 8(7). PMC: 4963860. DOI: 10.3390/nu8070380. View

11.

Hoang V, Matossian M, Ucar D, Elliott S, La J, Wright M . ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer. Front Oncol. 2020; 10:1164. PMC: 7416559. DOI: 10.3389/fonc.2020.01164. View

12.

Ishizawa K, Dorjsuren N, Izawa-Ishizawa Y, Sugimoto R, Ikeda Y, Kihira Y . Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. J Endocrinol. 2009; 202(2):309-16. DOI: 10.1677/JOE-08-0469. View

13.

Ma C, Geng B, Zhang X, Li R, Yang X, Xia Y . Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway. Med Sci Monit. 2020; 26:e918370. PMC: 6977602. DOI: 10.12659/MSM.918370. View

14.

de Jong P, Taniguchi K, Harris A, Bertin S, Takahashi N, Duong J . ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nat Commun. 2016; 7:11551. PMC: 4873670. DOI: 10.1038/ncomms11551. View

15.

Kawakami T, Park S, Kaku R, Yang J . Extracellular-regulated-kinase 5-mediated renal protection against ischemia-reperfusion injury. Biochem Biophys Res Commun. 2012; 418(4):603-8. PMC: 3288778. DOI: 10.1016/j.bbrc.2012.01.043. View

16.

Zhai L, Ma C, Li W, Yang S, Liu Z . miR-143 suppresses epithelial-mesenchymal transition and inhibits tumor growth of breast cancer through down-regulation of ERK5. Mol Carcinog. 2015; 55(12):1990-2000. DOI: 10.1002/mc.22445. View

17.

Liu F, Zhang H, Song H . Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis. Oncol Rep. 2016; 37(1):83-90. DOI: 10.3892/or.2016.5256. View

18.

Dorado F, Velasco S, Esparis-Ogando A, Pericacho M, Pandiella A, Silva J . The mitogen-activated protein kinase Erk5 mediates human mesangial cell activation. Nephrol Dial Transplant. 2008; 23(11):3403-11. DOI: 10.1093/ndt/gfn333. View

19.

Giurisato E, Lonardi S, Telfer B, Lussoso S, Risa-Ebri B, Zhang J . Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis. Cancer Res. 2020; 80(16):3319-3330. PMC: 7611207. DOI: 10.1158/0008-5472.CAN-19-2416. View

20.

Bobick B, Matsche A, Chen F, Tuan R . The ERK5 and ERK1/2 signaling pathways play opposing regulatory roles during chondrogenesis of adult human bone marrow-derived multipotent progenitor cells. J Cell Physiol. 2010; 224(1):178-86. DOI: 10.1002/jcp.22120. View