Actinomycetes Associated with Arthropods As a Source of New Bioactive Compounds

Overview

Journal Curr Issues Mol Biol

Publisher MDPI

Specialty Molecular Biology

Date 2024 May 24

PMID 38785506

Authors

Carlos Olano

Miriam Rodriguez

Affiliations

Soon will be listed here.

Abstract

Antimicrobial resistance is one of the main global threats to human health in the 21st century due to the rapid appearance of bacterial resistance and the lack of novel bioactive compounds. Natural products, especially from Actinomycetes, remain the best source to refill the drug industry pipeline. Different strategies have been pursued to increase the chances of discovering new molecules, such as studying underexplored environments like arthropod symbionts, which represent a relevant reservoir for active metabolites. This review summarizes recent research on the identification of bioactive molecules produced by Actinomycetes associated with arthropods' microbiome. The metabolites have been categorized based on their structural properties and host, highlighting that multidisciplinary approaches will be the key to fully understanding this complex relationship.

Citing Articles

Diversity, antibacterial and phytotoxic activities of actinomycetes associated with .

Liu Q, Tao J, Kan L, Zhang Y, Zhang S PeerJ. 2024; 12:e18575.

PMID: 39611011 PMC: 11604042. DOI: 10.7717/peerj.18575.

An Overview of Lsr2 Repressor Effect in spp. Secondary Metabolism.

Cuervo L, Malmierca M, Olano C Microorganisms. 2024; 12(11).

PMID: 39597706 PMC: 11596768. DOI: 10.3390/microorganisms12112317.

Detection of Pharmaceutical Contamination in Amphipods of Lake Baikal by the HPLC-MS Method.

Telnova T, Morgunova M, Shashkina S, Vlasova A, Dmitrieva M, Shelkovnikova V Antibiotics (Basel). 2024; 13(8).

PMID: 39200038 PMC: 11350909. DOI: 10.3390/antibiotics13080738.

References

Bar-On Y, Phillips R, Milo R . The biomass distribution on Earth. Proc Natl Acad Sci U S A. 2018; 115(25):6506-6511. PMC: 6016768. DOI: 10.1073/pnas.1711842115. View

Alferova V, Maviza T, Biryukov M, Zakalyukina Y, Lukianov D, Skvortsov D . Biological evaluation and spectral characterization of a novel tetracenomycin X congener. Biochimie. 2021; 192:63-71. DOI: 10.1016/j.biochi.2021.09.014. View

Malmierca M, Perez-Victoria I, Martin J, Reyes F, Mendez C, Salas J . New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway. Appl Environ Microbiol. 2019; 86(3). PMC: 6974644. DOI: 10.1128/AEM.02453-19. View

Yoon S, Lee S, Hwang J, Benndorf R, Beemelmanns C, Chung S . Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis. Nutrients. 2019; 11(4). PMC: 6520714. DOI: 10.3390/nu11040765. View

Baltz R . Genome mining for drug discovery: cyclic lipopeptides related to daptomycin. J Ind Microbiol Biotechnol. 2021; 48(3-4). PMC: 9113097. DOI: 10.1093/jimb/kuab020. View

Bae M, Mevers E, Pishchany G, Whaley S, Rock C, Andes D . Chemical Exchanges between Multilateral Symbionts. Org Lett. 2021; 23(5):1648-1652. PMC: 8465764. DOI: 10.1021/acs.orglett.1c00068. View

Palmer C, Alper H . Expanding the Chemical Palette of Industrial Microbes: Metabolic Engineering for Type III PKS-Derived Polyketides. Biotechnol J. 2018; 14(1):e1700463. DOI: 10.1002/biot.201700463. View

Zhang M, Yang C, Xiao Y, Zhang B, Deng X, Yang L . Aurachin SS, a new antibiotic from Streptomyces sp. NA04227. J Antibiot (Tokyo). 2017; 70(7):853-855. DOI: 10.1038/ja.2017.50. View

Qin Z, Munnoch J, Devine R, Holmes N, Seipke R, Wilkinson K . Formicamycins, antibacterial polyketides produced by isolated from African plant-ants. Chem Sci. 2017; 8(4):3218-3227. PMC: 5414599. DOI: 10.1039/c6sc04265a. View

10.

Song Y, Zheng H, Peng A, Ma J, Lu D, Li X . Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp. J Nat Prod. 2019; 82(5):1114-1119. DOI: 10.1021/acs.jnatprod.8b00821. View

11.

Sivalingam P, Hong K, Pote J, Prabakar K . Extreme Environment : Potential Sources for New Antibacterial and Anticancer Drug Leads?. Int J Microbiol. 2019; 2019:5283948. PMC: 6636559. DOI: 10.1155/2019/5283948. View

12.

Malmierca M, Gonzalez-Montes L, Perez-Victoria I, Sialer C, Brana A, Garcia Salcedo R . Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines. Front Microbiol. 2018; 9:39. PMC: 5797532. DOI: 10.3389/fmicb.2018.00039. View

13.

Hoskisson P, Seipke R . Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism. mBio. 2020; 11(5). PMC: 7587438. DOI: 10.1128/mBio.02642-20. View

14.

Wenski S, Thiengmag S, Helfrich E . Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering. Synth Syst Biotechnol. 2022; 7(1):631-647. PMC: 8842026. DOI: 10.1016/j.synbio.2022.01.007. View

15.

Newman D, Cragg G . Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J Nat Prod. 2020; 83(3):770-803. DOI: 10.1021/acs.jnatprod.9b01285. View

16.

An J, Lim H, Lee J, Jang Y, Nam S, Lee S . Hamuramicin C, a Cytotoxic Bicyclic Macrolide Isolated from a Wasp Gut Bacterium. J Nat Prod. 2022; 85(4):936-942. DOI: 10.1021/acs.jnatprod.1c01075. View

17.

Stadler F . The maggot therapy supply chain: a review of the literature and practice. Med Vet Entomol. 2019; 34(1):1-9. DOI: 10.1111/mve.12397. View

18.

Guo Z, Wang R, Chen F, Liu T . Streptoxamine, an unprecedented benzoisoindole-deferoxamine hybrid from the locust-derived Streptomyces sp. HKHCa2. Fitoterapia. 2018; 127:25-28. DOI: 10.1016/j.fitote.2018.03.008. View

19.

Ding T, Yang L, Zhang W, Shen Y . The secondary metabolites of rare actinomycetes: chemistry and bioactivity. RSC Adv. 2022; 9(38):21964-21988. PMC: 9067109. DOI: 10.1039/c9ra03579f. View

20.

Kornfuehrer T, Eustaquio A . Diversification of polyketide structures synthase engineering. Medchemcomm. 2020; 10(8):1256-1272. PMC: 7053703. DOI: 10.1039/c9md00141g. View