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Sublobar Resection of Non-Small-Cell Lung Cancer: Wedge Resection Vs. Segmentectomy

Overview
Journal Curr Oncol
Publisher MDPI
Specialty Oncology
Date 2024 May 24
PMID 38785468
Authors
Affiliations
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Abstract

Lung cancer is the most common cause of cancer death. The mainstay treatment for non-small-cell lung cancer (NSCLC), particularly in the early stages, is surgical resection. Traditionally, lobectomy has been considered the gold-standard technique. Sublobar resection includes segmentectomy and wedge resection. Compared to lobectomy, these procedures have been viewed as a compromise procedure, reserved for those with poor cardiopulmonary function or who are poor surgical candidates for other reasons. However, with the advances in imaging and surgical techniques, the subject of sublobar resection as a curative treatment is being revisited. Many studies have now shown segmentectomy to be equivalent to lobectomy in patients with small (<2.0 cm), peripheral NSCLC. However, there is a mix of evidence when it comes to wedge resection and its suitability as a curative procedure. At this time, until more data can be found, segmentectomy should be considered before wedge resection for patients with early-stage NSCLC.

References
1.
Bedetti B, Bertolaccini L, Rocco R, Schmidt J, Solli P, Scarci M . Segmentectomy versus lobectomy for stage I non-small cell lung cancer: a systematic review and meta-analysis. J Thorac Dis. 2017; 9(6):1615-1623. PMC: 5506148. DOI: 10.21037/jtd.2017.05.79. View

2.
Lin H, Peng Z, Zhou K, Liang L, Cao J, Huang Z . Differential efficacy of segmentectomy and wedge resection in sublobar resection compared to lobectomy for solid-dominant stage IA lung cancer: a systematic review and meta-analysis. Int J Surg. 2023; 110(2):1159-1171. PMC: 10871577. DOI: 10.1097/JS9.0000000000000896. View

3.
Ost D, Yeung S, Tanoue L, Gould M . Clinical and organizational factors in the initial evaluation of patients with lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013; 143(5 Suppl):e121S-e141S. PMC: 4694609. DOI: 10.1378/chest.12-2352. View

4.
Altorki N, Wang X, Kozono D, Watt C, Landrenau R, Wigle D . Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer. N Engl J Med. 2023; 388(6):489-498. PMC: 10036605. DOI: 10.1056/NEJMoa2212083. View

5.
Sienel W, Dango S, Kirschbaum A, Cucuruz B, Horth W, Stremmel C . Sublobar resections in stage IA non-small cell lung cancer: segmentectomies result in significantly better cancer-related survival than wedge resections. Eur J Cardiothorac Surg. 2008; 33(4):728-34. DOI: 10.1016/j.ejcts.2007.12.048. View