The Intertwining of Oxytocin's Effects on Social Affiliation and Inflammation

Overview

Journal Compr Psychoneuroendocrinol

Date 2024 May 24

PMID 38784104

Authors

Marcy A Kingsbury

Affiliations

Soon will be listed here.

Abstract

•Oxytocin is an ancient adaptive hormone that promotes social affiliation to maximize fitness and longevity.•Oxytocin is a multifaceted hormone that regulates stress responses at all levels of cellular organization within individuals.•Oxytocin's dual actions on sociability and inflammation highlight its powerful capacity as a modulator of human health.

Citing Articles

Oxytocin: Not "just a female hormone": A very special issue and a very special molecule.

Carter C, Bluthe R, Connelly J, Kingsbury M Compr Psychoneuroendocrinol. 2025; 20():100273.

PMID: 39801534 PMC: 11725094. DOI: 10.1016/j.cpnec.2024.100273.

Is Oxytocin Induction at Labor a Risk Factor for Developmental Hip Dysplasia?.

Emral L, Taskin E, Albayrak A, Arslan M, Soylu D J Clin Med. 2024; 13(19).

PMID: 39407784 PMC: 11477270. DOI: 10.3390/jcm13195724.

References

Kingsbury M, Bilbo S . The inflammatory event of birth: How oxytocin signaling may guide the development of the brain and gastrointestinal system. Front Neuroendocrinol. 2019; 55:100794. DOI: 10.1016/j.yfrne.2019.100794. View

Klatt J, Goodson J . Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird. Proc Biol Sci. 2012; 280(1750):20122396. PMC: 3574448. DOI: 10.1098/rspb.2012.2396. View

Mairesse J, Zinni M, Pansiot J, Hassan-Abdi R, Demene C, Colella M . Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia. Glia. 2018; 67(2):345-359. DOI: 10.1002/glia.23546. View

Carter C . Close encounters with oxytocin. Compr Psychoneuroendocrinol. 2023; 15:100189. PMC: 10422098. DOI: 10.1016/j.cpnec.2023.100189. View

Goodson J, Schrock S, Klatt J, Kabelik D, Kingsbury M . Mesotocin and nonapeptide receptors promote estrildid flocking behavior. Science. 2009; 325(5942):862-6. PMC: 2862247. DOI: 10.1126/science.1174929. View

Lagercrantz H, Slotkin T . The "stress" of being born. Sci Am. 1986; 254(4):100-7. DOI: 10.1038/scientificamerican0486-100. View

Yuan L, Liu S, Bai X, Gao Y, Liu G, Wang X . Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice. J Neuroinflammation. 2016; 13(1):77. PMC: 4831099. DOI: 10.1186/s12974-016-0541-7. View

Carter C, Kenkel W, MacLean E, Wilson S, Perkeybile A, Yee J . Is Oxytocin "Nature's Medicine"?. Pharmacol Rev. 2020; 72(4):829-861. PMC: 7495339. DOI: 10.1124/pr.120.019398. View

Carter C . Oxytocin and love: Myths, metaphors and mysteries. Compr Psychoneuroendocrinol. 2022; 9:100107. PMC: 9216351. DOI: 10.1016/j.cpnec.2021.100107. View

10.

Carter C, Kingsbury M . Oxytocin and oxygen: the evolution of a solution to the 'stress of life'. Philos Trans R Soc Lond B Biol Sci. 2022; 377(1858):20210054. PMC: 9272143. DOI: 10.1098/rstb.2021.0054. View

11.

Finlay B, Darlington R . Linked regularities in the development and evolution of mammalian brains. Science. 1995; 268(5217):1578-84. DOI: 10.1126/science.7777856. View

12.

Goodson J, Kingsbury M . What's in a name? Considerations of homologies and nomenclature for vertebrate social behavior networks. Horm Behav. 2013; 64(1):103-12. PMC: 4038951. DOI: 10.1016/j.yhbeh.2013.05.006. View

13.

Thompson R, Walton J . Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus). Behav Neurosci. 2004; 118(3):620-6. DOI: 10.1037/0735-7044.118.3.620. View

14.

Goodson J, Kingsbury M . Nonapeptides and the evolution of social group sizes in birds. Front Neuroanat. 2011; 5:13. PMC: 3049320. DOI: 10.3389/fnana.2011.00013. View

15.

Goodson J, Schrock S, Kingsbury M . Oxytocin mechanisms of stress response and aggression in a territorial finch. Physiol Behav. 2015; 141:154-63. DOI: 10.1016/j.physbeh.2015.01.016. View

16.

Cabungcal J, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch T . Perineuronal nets protect fast-spiking interneurons against oxidative stress. Proc Natl Acad Sci U S A. 2013; 110(22):9130-5. PMC: 3670388. DOI: 10.1073/pnas.1300454110. View

17.

Goodson J, Kelly A, Kingsbury M . Evolving nonapeptide mechanisms of gregariousness and social diversity in birds. Horm Behav. 2012; 61(3):239-50. PMC: 3312996. DOI: 10.1016/j.yhbeh.2012.01.005. View

18.

Klein B, Tamir H, Ludwig R, Glickstein S, Welch M, Anwar M . Colostrum oxytocin modulates cellular stress response, inflammation, and autophagy markers in newborn rat gut villi. Biochem Biophys Res Commun. 2017; 487(1):47-53. DOI: 10.1016/j.bbrc.2017.04.011. View

19.

Klein B, Tamir H, Hirschberg D, Glickstein S, Ludwig R, Welch M . Oxytocin modulates markers of the unfolded protein response in Caco2BB gut cells. Cell Stress Chaperones. 2013; 19(4):465-77. PMC: 4041945. DOI: 10.1007/s12192-013-0473-4. View

20.

Varian B, Weber K, Erdman S . Oxytocin and the microbiome. Compr Psychoneuroendocrinol. 2023; 16:100205. PMC: 10724733. DOI: 10.1016/j.cpnec.2023.100205. View