Epigenome-metabolism Nexus in the Retina: Implications for Aging and Disease

Overview

Journal Trends Genet

Specialty Genetics

Date 2024 May 23

PMID 38782642

Authors

Anupam K Mondal

Mohita Gaur

Jayshree Advani

Anand Swaroop

Affiliations

Soon will be listed here.

Abstract

Intimate links between epigenome modifications and metabolites allude to a crucial role of cellular metabolism in transcriptional regulation. Retina, being a highly metabolic tissue, adapts by integrating inputs from genetic, epigenetic, and extracellular signals. Precise global epigenomic signatures guide development and homeostasis of the intricate retinal structure and function. Epigenomic and metabolic realignment are hallmarks of aging and highlight a link of the epigenome-metabolism nexus with aging-associated multifactorial traits affecting the retina, including age-related macular degeneration and glaucoma. Here, we focus on emerging principles of epigenomic and metabolic control of retinal gene regulation, with emphasis on their contribution to human disease. In addition, we discuss potential mitigation strategies involving lifestyle changes that target the epigenome-metabolome relationship for maintaining retinal function.

Citing Articles

Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina.

Yuan Y, Biswas P, Zemke N, Dang K, Wu Y, DAntonio M bioRxiv. 2025; .

PMID: 39764062 PMC: 11703273. DOI: 10.1101/2024.12.28.630634.

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