» Articles » PMID: 38776413

An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians

Overview
Journal Diabetes
Specialty Endocrinology
Date 2024 May 22
PMID 38776413
Authors
Affiliations
Soon will be listed here.
Abstract

Article Highlights:

Citing Articles

Reduced circulating sphingolipids and activity are linked to T2D risk and impaired insulin secretion.

Khan S, Ye W, Van J, Singh I, Rabiee Y, Rodricks K Sci Adv. 2025; 11(2):eadr1725.

PMID: 39792658 PMC: 11790001. DOI: 10.1126/sciadv.adr1725.

References
1.
Ravussin E, Lillioja S, Knowler W, Christin L, Freymond D, Abbott W . Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med. 1988; 318(8):467-72. DOI: 10.1056/NEJM198802253180802. View

2.
Summers S . Could Ceramides Become the New Cholesterol?. Cell Metab. 2018; 27(2):276-280. DOI: 10.1016/j.cmet.2017.12.003. View

3.
Lillioja S, Mott D, Zawadzki J, Young A, Abbott W, Bogardus C . Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance. J Clin Endocrinol Metab. 1986; 62(5):922-7. DOI: 10.1210/jcem-62-5-922. View

4.
Raichur S, Wang S, Chan P, Li Y, Ching J, Chaurasia B . CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab. 2014; 20(4):687-95. DOI: 10.1016/j.cmet.2014.09.015. View

5.
Turpin-Nolan S, Bruning J . The role of ceramides in metabolic disorders: when size and localization matters. Nat Rev Endocrinol. 2020; 16(4):224-233. DOI: 10.1038/s41574-020-0320-5. View