Ethics of Using Animal Models As Predictors of Human Response in Tissue Engineering

Overview

Journal Ethics Biol Eng Med

Publisher Begell House

Date 2024 May 21

PMID 38770223

Authors

Jessica M Falcon

James P Karchner

Elizabeth A Henning

Robert L Mauck

Nancy Pleshko

Affiliations

Soon will be listed here.

Abstract

Use of outcomes from animal research for prediction of human response in tissue engineering studies has many ethical considerations. This article aims to contribute to the ethical discussion by delineating the framework of animal research and the ethical considerations at play, in particular with respect to cartilage tissue engineering. The history of animal research regulation and the current status of animal research in orthopedic tissue engineering is discussed. Questions addressed include how the proper animal models are chosen, how regulatory bodies ensure animal wellness and safety, and how guidelines are implemented and maintained throughout the life cycle of a project. Finally, we provide examples of both and cartilage tissue engineering research where animal models were employed as a predictive model of human response.

Citing Articles

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review.

de Kanter A, Jongsma K, Verhaar M, Bredenoord A Tissue Eng Part B Rev. 2022; 29(2):167-187.

PMID: 36112697 PMC: 10122262. DOI: 10.1089/ten.TEB.2022.0033.

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