Regulation of Cancer-Associated MiRNAs Expression Under Hypoxic Conditions

Overview

Journal Anal Cell Pathol (Amst)

Specialties Cell Biology
Oncology
Pathology

Date 2024 May 20

PMID 38766303

Authors

Jesus Valencia-Cervantes

Martha Patricia Sierra-Vargas

Affiliations

Soon will be listed here.

Abstract

Solid tumors frequently experience hypoxia or low O levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1) is activated and acts as a transcription factor that regulates cancer cell adaptation to O and nutrient deprivation. HIF-1 controls gene expression associated with various signaling pathways that promote cancer cell proliferation and survival. MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs that play a role in various biological processes essential for cancer progression. This review presents an overview of how hypoxia regulates the expression of multiple miRNAs in the progression of cancer cells.

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