Effect of Akkermansia Muciniphila on Pancreatic Islet β-cell Function in Rats with Prediabetes Mellitus Induced by a High-fat Diet

Overview

Journal Bioresour Bioprocess

Specialty Biochemistry

Date 2024 May 19

PMID 38763955

Authors

Shuai Yan

Lin Chen

Na Li

Xiaohui Wei

Jingjing Wang

Weiping Dong

Yufan Wang

Jianxia Shi

Xiaoying Ding

Yongde Peng

Affiliations

Soon will be listed here.

Abstract

Prediabetes is an important stage in the development of diabetes. It is necessary to find a safe, effective and sustainable way to delay and reverse the progression of prediabetes. Akkermansia muciniphila (A. muciniphila) is one of the key bacteria associated with glucose metabolism. Recent studies mainly focus on the effect of A. muciniphila on obesity and insulin resistance, but there is no research on the effect of A. muciniphila on pancreatic β-cell function and its mechanism in prediabetes. In this study, we investigated the effects of A. muciniphila on β-cell function, apoptosis and differentiation, as well as its effects on the gut microbiome, intestinal barrier, metaflammation and the expression of Toll-like receptors (TLRs) in a high-fat diet (HFD)-induced prediabetic rat model. The effect of A. muciniphila was compared with dietary intervention. The results showed both A. muciniphila treatment and dietary intervention can reduce metaflammation by repairing the intestinal barrier in rats with prediabetes induced by an HFD and improve β-cell secretory function, apoptosis and differentiation through signaling pathways mediated by TLR2 and TLR4. Additionally, A. muciniphila can further elevate β-cell secretion, attenuate apoptosis and improve differentiation and the TLR signaling pathway on the basis of diet.

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