» Articles » PMID: 38760983

The Role of Neuroestrogens in the Estrogen-induced Gonadotropin Surge in Male Monkeys

Overview
Specialty Endocrinology
Date 2024 May 18
PMID 38760983
Authors
Affiliations
Soon will be listed here.
Abstract

Neuroestrogens locally synthesized in the brain are known to play a role in sexual behaviors. However, the question of whether neuroestrogens are involved in the regulation of the gonadotropin-releasing hormone (GnRH) release is just emerging. Because previous studies in this lab indicate that neuroestradiol is also important for the pulsatile release as well as the surge release of GnRH in female rhesus monkeys, in the present study, we examined whether neuroestradiol plays a role in the estrogen-induced LH surge in orchidectomized (ORX) male rhesus monkeys. Unlike in rodents, it is known that a high dose of estrogen treatment can result in the LH surge in ORX male rhesus monkeys. Results that the administration of the aromatase inhibitor, letrozole, failed to attenuate the estrogen-induced LH surge, suggest that unlike in ovariectomized females, neuroestrogens do not play a role in the LH surge experimentally induced by the exogenous estrogen treatment in ORX male monkeys.

References
1.
Sanghera M, Simpson E, McPhaul M, Kozlowski G, Conley A, Lephart E . Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodies. Endocrinology. 1991; 129(6):2834-44. DOI: 10.1210/endo-129-6-2834. View

2.
Kuchuk N, van Schoor N, Pluijm S, Smit J, de Ronde W, Lips P . The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. Clin Endocrinol (Oxf). 2007; 67(2):295-303. DOI: 10.1111/j.1365-2265.2007.02882.x. View

3.
Pau K, Gliessman P, Hess D, Spies H . Effects of estrogen on hypothalamic gonadotropin-releasing hormone release in castrated male rhesus macaques. Brain Res. 1988; 459(1):70-5. DOI: 10.1016/0006-8993(88)90287-9. View

4.
Hess D, Wilkins R, Moossy J, Chang J, Plant T, McCormack J . Estrogen-induced gonadotropin surges in decerebrated female rhesus monkeys with medial basal hypothalamic peninsulae. Endocrinology. 1977; 101(4):1264-71. DOI: 10.1210/endo-101-4-1264. View

5.
Dungan H, Clifton D, Steiner R . Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology. 2005; 147(3):1154-8. DOI: 10.1210/en.2005-1282. View