The Prezygotic Origin of Structural Mosaicisms
Overview
Affiliations
A theoretical model to explain the occurrence of some structural mosaicisms is proposed. It is based on a prezygotic (meiotic) half chromatid mutation leading, after the first post-zygotic DNA replication, to a structural mosaic.
Germline and somatic mosaicism in a female carrier of Hunter disease.
Froissart R, Maire I, Bonnet V, Levade T, Bozon D J Med Genet. 1997; 34(2):137-40.
PMID: 9039991 PMC: 1050868. DOI: 10.1136/jmg.34.2.137.
Somatic origin of inherited haemophilia A.
Brocker-Vriends A, Briet E, Dreesen J, Bakker B, Reitsma P, Pannekoek H Hum Genet. 1990; 85(3):288-92.
PMID: 1975557 DOI: 10.1007/BF00206748.