Cardioprotective Effects of Vaccination in Hospitalized Patients with COVID-19

Overview

Journal Clin Exp Med

Specialty General Medicine

Date 2024 May 17

PMID 38758248

Authors

Julian Madrid

Prerana Agarwal

Katharina Muller-Peltzer

Leo Benning

Mischa Selig

Bernd Rolauffs

Philipp Diehl

Johannes Kalbhenn

Georg Trummer

Stefan Utzolino

Tobias Wengenmayer

Hans-Jorg Busch

Daiana Stolz

Siegbert Rieg

Marcus Panning

Fabian Bamberg

Christopher L Schlett

Esther Askani

Affiliations

Soon will be listed here.

Abstract

COVID-19 vaccination has been shown to prevent and reduce the severity of COVID-19 disease. The aim of this study was to explore the cardioprotective effect of COVID-19 vaccination in hospitalized COVID-19 patients. In this retrospective, single-center cohort study, we included hospitalized COVID-19 patients with confirmed vaccination status from July 2021 to February 2022. We assessed outcomes such as acute cardiac events and cardiac biomarker levels through clinical and laboratory data. Our analysis covered 167 patients (69% male, mean age 58 years, 42% being fully vaccinated). After adjustment for confounders, vaccinated hospitalized COVID-19 patients displayed a reduced relative risk for acute cardiac events (RR: 0.33, 95% CI [0.07; 0.75]) and showed diminished troponin T levels (Cohen's d: - 0.52, 95% CI [- 1.01; - 0.14]), compared to their non-vaccinated peers. Type 2 diabetes (OR: 2.99, 95% CI [1.22; 7.35]) and existing cardiac diseases (OR: 4.31, 95% CI [1.83; 10.74]) were identified as significant risk factors for the emergence of acute cardiac events. Our findings suggest that COVID-19 vaccination may confer both direct and indirect cardioprotective effects in hospitalized COVID-19 patients.

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