Radix Ameliorates Chronic Kidney Disease by Reshaping Gut Microbiota and Downregulating Wnt/β‑catenin Signaling

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2024 May 17

PMID 38757304

Authors

Peng Wu

Jingwen Xue

Zhangrui Zhu

Yao Yu

Qi Sun

Ming Xie

Benlin Wang

Pengcheng Huang

Zhengyuan Feng

Jie Zhao

Affiliations

Soon will be listed here.

Abstract

Gut microbiota dysfunction is a key factor affecting chronic kidney disease (CKD) susceptibility. Radix (PLR), a traditional Chinese medicine and food homologous herb, is known to promote the gut microbiota homeostasis; however, its role in renoprotection remains unknown. The present study aimed to investigate the efficacy and potential mechanism of PLR to alleviate CKD. An 8‑week 2% NaCl‑feeding murine model was applied to induce CKD and evaluate the therapeutic effect of PLR supplementary. After gavage for 8 weeks, The medium and high doses of PLR significantly alleviated CKD‑associated creatinine, urine protein increasement and nephritic histopathological injury. Moreover, PLR protected kidney from fibrosis by reducing inflammatory response and downregulating the canonical Wnt/β‑catenin pathway. Furthermore, PLR rescued the gut microbiota dysbiosis and protected against high salt‑induced gut barrier dysfunction. Enrichment of and was found after PLR intervention, the relative abundances of which were in positive correlation with normal maintenance of renal histology and function. Next, fecal microbiota transplantation experiment verified that the positive effect of PLR on CKD was, at least partially, exerted through gut microbiota reestablishment and downregulation of the Wnt/β‑catenin pathway. The present study provided evidence for a new function of PLR on kidney protection and put forward a potential therapeutic strategy target for CKD.

Citing Articles

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PMID: 39114641 PMC: 11303303. DOI: 10.3389/fnmol.2024.1427054.

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