The Immunomodulatory Mechanism of Acupuncture Treatment for Ischemic Stroke: Research Progress, Prospects, and Future Direction

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 May 17

PMID 38756772

Authors

Hongjun Kuang

Xinzhou Zhu

Huan Chen

Han Tang

Hong Zhao

Affiliations

Soon will be listed here.

Abstract

Ischemic stroke (IS) is one of the leading causes of death and disability. Complicated mechanisms are involved in the pathogenesis of IS. Immunomodulatory mechanisms are crucial to IS. Acupuncture is a traditional non-drug treatment that has been extensively used to treat IS. The exploration of neuroimmune modulation will broaden the understanding of the mechanisms underlying acupuncture treatment. This review summarizes the immune response of immune cells, immune cytokines, and immune organs after an IS. The immunomodulatory mechanisms of acupuncture treatment on the central nervous system and peripheral immunity, as well as the factors that influence the effects of acupuncture treatment, were summarized. We suggest prospects and future directions for research on immunomodulatory mechanisms of acupuncture treatment for IS based on current progress, and we hope that these will provide inspiration for researchers. Additionally, acupuncture has shown favorable outcomes in the treatment of immune-based nervous system diseases, generating new directions for research on possible targets and treatments for immune-based nervous system diseases.

Citing Articles

Electroacupuncture Pretreatment Reduces Ischemic Brain Injury by Inhibiting the Lactate Production and Its Derived Protein Lactylation Formation.

Pan X, Zhang Y, Gan Y, Zhang J, Gao S, Feng X CNS Neurosci Ther. 2025; 31(1):e70231.

PMID: 39834103 PMC: 11746925. DOI: 10.1111/cns.70231.

Electroacupuncture reduces inflammatory damage following cerebral ischemia-reperfusion by enhancing ABCA1-mediated efferocytosis in M2 microglia.

Liao Y, Zhang T, Tang Y, Yu P, Liu Y, Yuan J Mol Brain. 2024; 17(1):61.

PMID: 39223647 PMC: 11367741. DOI: 10.1186/s13041-024-01135-0.

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