NET-targeted Nanoparticles for Antithrombotic Therapy in Pregnancy

Overview

Journal iScience

Publisher Cell Press

Date 2024 May 17

PMID 38756418

Authors

Yijie Zhou

Lin Xu

Pingsong Jin

Na Li

Xuehai Chen

Anyu Yang

Hongbo Qi

Affiliations

Soon will be listed here.

Abstract

Pulmonary embolism caused by deep vein thrombosis (DVT) is a major contributor to maternal morbidity and mortality. There is still an unmet need for safe and effective treatment options for DVT during pregnancy. Recent research has shown that neutrophil extracellular trap (NET) formation plays a very vital role in thrombosis. We created nanoparticles surface-modified by neutrophil elastase (NE)-binding peptide that can target activated neutrophils specifically and . Prussian blue nanoparticles (PB NPs) designed in the core scavenges abnormally elevated reactive oxygen species (ROS) in the vascular microenvironment and acts as a photothermal agent to mediate photothermal therapy (PTT) to damage fibrin network structure. Based on the data we have included, this noninvasive therapeutic approach is considered safe for both mothers and the fetus. Furthermore, our findings indicate that this therapeutic approach has a significant alleviation effect on intrauterine growth restriction caused by maternal thrombosis.

Citing Articles

Physicochemical Design of Nanoparticles to Interface with and Degrade Neutrophil Extracellular Traps.

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Application of Nanomaterials Targeting Immune Cells in the Treatment of Chronic Inflammation.

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