Metastatic Epithelioid Hemangioendothelioma of the Bone: A Case Report and Literature Review

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 May 17

PMID 38756281

Authors

Jihane Derfoufi

Mouhsine Omari

Younesse Najioui

Anass Haloui

Ouissam Al Jarroudi

Amal Bennani

Sami Aziz Brahmi

Said Afqir

Affiliations

Soon will be listed here.

Abstract

Epithelioid hemangioendothelioma (EHE) is an extremely rare vascular tumor, which can pose a diagnostic dilemma. It affects women more than men and is mainly found in the liver, lung, and bone. To date, there are no known predisposing factors. Limited data are available on the management of EHE at metastatic stages. The only optimal treatments to prevent metastatic dissemination are surgical resection and amputation in addition to radiotherapy at early stages. The oncologist in this rare entity plays an important role in the guided and standardized management of this disease, especially for advanced stages. In this article, we report the case of a 74-year-old patient admitted with swelling on the outer aspect of the right calf associated with pain and total functional impairment of the limb. The diagnosis favored a high-risk vascular tumor resembling EHE, confirmed by bone (tibia) and soft tissue biopsy. The patient underwent staging investigations, revealing diffuse metastases to the liver, bones, and lungs. The objective of this article is to advocate for oncological intervention in this entity, particularly in the advanced stages of the disease. Despite its rarity, the advancement of clinical trials and therapeutic recommendations remains crucial for optimal treatment.

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