Identification of Biomarkers and Potential Therapeutic Targets for Pancreatic Cancer by Proteomic Analysis in Two Prospective Cohorts

Overview

Journal Cell Genom

Date 2024 May 16

PMID 38754433

Authors

Jingjing Lyu

Minghui Jiang

Ziwei Zhu

Hongji Wu

Haonan Kang

Xingjie Hao

Shanshan Cheng

Huan Guo

Xia Shen

Tangchun Wu

Jiang Chang

Chaolong Wang

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer (PC) is the deadliest malignancy due to late diagnosis. Aberrant alterations in the blood proteome might serve as biomarkers to facilitate early detection of PC. We designed a nested case-control study of incident PC based on a prospective cohort of 38,295 elderly Chinese participants with ∼5.7 years' follow-up. Forty matched case-control pairs passed the quality controls for the proximity extension assay of 1,463 serum proteins. With a lenient threshold of p < 0.005, we discovered regenerating family member 1A (REG1A), REG1B, tumor necrosis factor (TNF), and phospholipase A2 group IB (PLA2G1B) in association with incident PC, among which the two REG1 proteins were replicated using the UK Biobank Pharma Proteomics Project, with effect sizes increasing steadily as diagnosis time approaches the baseline. Mendelian randomization analysis further supported the potential causal effects of REG1 proteins on PC. Taken together, circulating REG1A and REG1B are promising biomarkers and potential therapeutic targets for the early detection and prevention of PC.

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