Effect of Massive Bowel Resection on Enteroinsular Axis

Overview

Journal Gut

Specialty Gastroenterology

Date 1979 Sep 1

PMID 387543

Citations 5

Authors

T Kajawara

T Szuki

T Tobe

Affiliations

Soon will be listed here.

Abstract

Pancreatic endocrine function was studied in 13 patients who had undergone massive bowel resection. The patients were divided into two groups: one month after operation (short-term group), and three or more months after operation (long-term group). Oral administration of glucose caused a persistent low insulin secretion in almost all the patients and the glucose tolerance curve showed a diabetic pattern in four. In contrast, the insulin response to intravenously infused arginine was impaired in the short-term group, but was at an approximately normal level in the long-term group. Pancreatic glucagon response to intravenous arginine, however, remained unchanged in both groups. Interruption of the enteroinsular axis as the result of massive bowel resection probably plays a major part in this discrepancy of the behaviour of insulin in the long-term group.

Citing Articles

Alterations in pancreatic islet cell function in response to small bowel resection.

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Intestinal resection-associated metabolic syndrome.

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Gut hormone release after intestinal resection.

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Gastric inhibitory polypeptide secretion after radical pancreatoduodenectomy.

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Gastric acid secretion and gastrin production in the short bowel syndrome.

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