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PET Imaging of Metabolism, Perfusion, and Hypoxia: FDG and Beyond

Overview
Journal Cancer J
Specialty Oncology
Date 2024 May 16
PMID 38753750
Authors
Austin R Pantel
Seong-Woo Bae
Elizabeth J Li
Sophia R OBrien
H Charles Manning
Affiliations
Soon will be listed here.
Abstract

Imaging glucose metabolism with [18F]fluorodeoxyglucose positron emission tomography has transformed the diagnostic and treatment algorithms of numerous malignancies in clinical practice. The cancer phenotype, though, extends beyond dysregulation of this single pathway. Reprogramming of other pathways of metabolism, as well as altered perfusion and hypoxia, also typifies malignancy. These features provide other opportunities for imaging that have been developed and advanced into humans. In this review, we discuss imaging metabolism, perfusion, and hypoxia in cancer, focusing on the underlying biology to provide context. We conclude by highlighting the ability to image multiple facets of biology to better characterize cancer and guide targeted treatment.

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