Static and Dynamic Brain Morphological Changes in Isolated REM Sleep Behavior Disorder Compared to Normal Aging

Overview

Journal Front Neurosci

Date 2024 May 16

PMID 38751861

Authors

Gilsoon Park

Hyunjin Jo

Yaqiong Chai

Hea Ree Park

Hanul Lee

Eun Yeon Joo

Hosung Kim

Affiliations

Soon will be listed here.

Abstract

Objective/background: To assess whether cerebral structural alterations in isolated rapid eye movement sleep behavior disorder (iRBD) are progressive and differ from those of normal aging and whether they are related to clinical symptoms.

Patients/methods: In a longitudinal study of 18 patients with iRBD (age, 66.1 ± 5.7 years; 13 males; follow-up, 1.6 ± 0.6 years) and 24 age-matched healthy controls (age, 67.0 ± 4.9 years; 12 males; follow-up, 2.0 ± 0.9 years), all participants underwent multiple extensive clinical examinations, neuropsychological tests, and magnetic resonance imaging at baseline and follow-up. Surface-based cortical reconstruction and automated subcortical structural segmentation were performed on T1-weighted images. We used mixed-effects models to examine the differences between the groups and the differences in anatomical changes over time.

Results: None of the patients with iRBD demonstrated phenoconversion during the follow-up. Patients with iRBD had thinner cortices in the frontal, occipital, and temporal regions, and more caudate atrophy, compared to that in controls. In similar regions, group-by-age interaction analysis revealed that patients with iRBD demonstrated significantly slower decreases in cortical thickness and caudate volume with aging than that observed in controls. Patients with iRBD had lower scores on the Korean version of the Mini-Mental Status Examination ( = 0.037) and frontal and executive functions ( = 0.049) at baseline than those in controls; however, no significant group-by-age interaction was identified.

Conclusion: Patients with iRBD show brain atrophy in the regions that are overlapped with the areas that have been documented to be affected in early stages of Parkinson's disease. Such atrophy in iRBD may not be progressive but may be slower than that in normal aging. Cognitive impairment in iRBD is not progressive.

References

Youn S, Kim T, Yoon I, Jeong J, Kim H, Han J . Progression of cognitive impairments in idiopathic REM sleep behaviour disorder. J Neurol Neurosurg Psychiatry. 2015; 87(8):890-6. DOI: 10.1136/jnnp-2015-311437. View

Sabuncu M, Desikan R, Sepulcre J, Yeo B, Liu H, Schmansky N . The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011; 68(8):1040-8. PMC: 3248949. DOI: 10.1001/archneurol.2011.167. View

DeLuca J, Diamond B . Aneurysm of the anterior communicating artery: a review of neuroanatomical and neuropsychological sequelae. J Clin Exp Neuropsychol. 1995; 17(1):100-21. DOI: 10.1080/13803399508406586. View

Cho J, Jeong Y, Lee Y, Hong S, Yoon J, Kim J . The Korean version of the Sniffin' stick (KVSS) test and its validity in comparison with the cross-cultural smell identification test (CC-SIT). Auris Nasus Larynx. 2008; 36(3):280-6. DOI: 10.1016/j.anl.2008.07.005. View

Phillips S, Sangalang V, Sterns G . Basal forebrain infarction. A clinicopathologic correlation. Arch Neurol. 1987; 44(11):1134-8. DOI: 10.1001/archneur.1987.00520230024008. View

Collins D, Neelin P, Peters T, Evans A . Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr. 1994; 18(2):192-205. View

Chen M, Li Y, Chen J, Gao L, Sun J, Gu Z . Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder. J Neuroradiol. 2020; 49(1):66-72. DOI: 10.1016/j.neurad.2020.04.007. View

Sateia M . International classification of sleep disorders-third edition: highlights and modifications. Chest. 2014; 146(5):1387-1394. DOI: 10.1378/chest.14-0970. View

MacDonald D, Kabani N, Avis D, Evans A . Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI. Neuroimage. 2000; 12(3):340-56. DOI: 10.1006/nimg.1999.0534. View

10.

Park J, Koh S, Kwon K, Kim S, Kim J, Kim J . Validation Study of the Official Korean Version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale. J Clin Neurol. 2020; 16(4):633-645. PMC: 7541990. DOI: 10.3988/jcn.2020.16.4.633. View

11.

Postuma R, Iranzo A, Hu M, Hogl B, Boeve B, Manni R . Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain. 2019; 142(3):744-759. PMC: 6391615. DOI: 10.1093/brain/awz030. View

12.

Fantini M, Farini E, Ortelli P, Zucconi M, Manconi M, Cappa S . Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep. 2011; 34(5):619-25. PMC: 3079941. View

13.

Arnulf I, Neutel D, Herlin B, Golmard J, Leu-Semenescu S, Cochen De Cock V . Sleepiness in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease. Sleep. 2015; 38(10):1529-35. PMC: 4576326. DOI: 10.5665/sleep.5040. View

14.

Hanyu H, Inoue Y, Sakurai H, Kanetaka H, Nakamura M, Miyamoto T . Voxel-based magnetic resonance imaging study of structural brain changes in patients with idiopathic REM sleep behavior disorder. Parkinsonism Relat Disord. 2011; 18(2):136-9. DOI: 10.1016/j.parkreldis.2011.08.023. View

15.

Tohka J, Zijdenbos A, Evans A . Fast and robust parameter estimation for statistical partial volume models in brain MRI. Neuroimage. 2004; 23(1):84-97. DOI: 10.1016/j.neuroimage.2004.05.007. View

16.

Sled J, Zijdenbos A, Evans A . A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging. 1998; 17(1):87-97. DOI: 10.1109/42.668698. View

17.

Rahayel S, Gaubert M, Postuma R, Montplaisir J, Carrier J, Monchi O . Brain atrophy in Parkinson's disease with polysomnography-confirmed REM sleep behavior disorder. Sleep. 2019; 42(6). PMC: 6559168. DOI: 10.1093/sleep/zsz062. View

18.

Han C, Jo S, Jo I, Kim E, Park M, Kang Y . An adaptation of the Korean mini-mental state examination (K-MMSE) in elderly Koreans: demographic influence and population-based norms (the AGE study). Arch Gerontol Geriatr. 2007; 47(3):302-10. DOI: 10.1016/j.archger.2007.08.012. View

19.

Wu P, Yu H, Peng S, Dauvilliers Y, Wang J, Ge J . Consistent abnormalities in metabolic network activity in idiopathic rapid eye movement sleep behaviour disorder. Brain. 2014; 137(Pt 12):3122-8. PMC: 4240297. DOI: 10.1093/brain/awu290. View

20.

Park G, Hong J, Duffy B, Lee J, Kim H . White matter hyperintensities segmentation using the ensemble U-Net with multi-scale highlighting foregrounds. Neuroimage. 2021; 237:118140. PMC: 8382044. DOI: 10.1016/j.neuroimage.2021.118140. View