Metabolomics Combined with Mathematical Analysis Reveals Metabolic Pathways Specific to Metastatic Cancers

Overview

Journal Transl Breast Cancer Res

Publisher AME Publishing Company

Date 2024 May 16

PMID 38751674

Authors

Shinya Sato

Toshinari Yamashita

Affiliations

Soon will be listed here.

References

Halma M, Tuszynski J, Marik P . Cancer Metabolism as a Therapeutic Target and Review of Interventions. Nutrients. 2023; 15(19). PMC: 10574675. DOI: 10.3390/nu15194245. View

Nakasuka F, Tabata S, Sakamoto T, Hirayama A, Ebi H, Yamada T . TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers. Commun Biol. 2021; 4(1):782. PMC: 8225889. DOI: 10.1038/s42003-021-02323-7. View

Guertin D, Wellen K . Acetyl-CoA metabolism in cancer. Nat Rev Cancer. 2023; 23(3):156-172. PMC: 11137663. DOI: 10.1038/s41568-022-00543-5. View

. AACR Project GENIE: Powering Precision Medicine through an International Consortium. Cancer Discov. 2017; 7(8):818-831. PMC: 5611790. DOI: 10.1158/2159-8290.CD-17-0151. View

Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G . Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006; 10(1):51-64. PMC: 2857533. DOI: 10.1016/j.ccr.2006.06.001. View

Sato S, Hiruma T, Koizumi M, Yoshihara M, Nakamura Y, Tadokoro H . Bone marrow adipocytes induce cancer-associated fibroblasts and immune evasion, enhancing invasion and drug resistance. Cancer Sci. 2023; 114(6):2674-2688. PMC: 10236619. DOI: 10.1111/cas.15786. View

Weber G . Metabolism in cancer metastasis. Int J Cancer. 2015; 138(9):2061-6. DOI: 10.1002/ijc.29839. View

Simpson N, Tryndyak V, Pogribna M, Beland F, Pogribny I . Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics. 2012; 7(12):1413-20. PMC: 3528696. DOI: 10.4161/epi.22713. View

Delbrouck C, Kiweler N, Chen O, Pozdeev V, Haase L, Neises L . Formate promotes invasion and metastasis in reliance on lipid metabolism. Cell Rep. 2023; 42(9):113034. DOI: 10.1016/j.celrep.2023.113034. View

10.

Assi M, Kimmelman A . Impact of context-dependent autophagy states on tumor progression. Nat Cancer. 2023; 4(5):596-607. PMC: 10542907. DOI: 10.1038/s43018-023-00546-7. View

11.

Mathur D, Liao C, Lin W, La Ferlita A, Alaimo S, Taylor S . The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung. Cancer Res. 2023; 83(20):3478-3491. PMC: 10570685. DOI: 10.1158/0008-5472.CAN-23-0153. View

12.

Lehuede C, Dupuy F, Rabinovitch R, Jones R, Siegel P . Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis. Cancer Res. 2016; 76(18):5201-8. DOI: 10.1158/0008-5472.CAN-16-0266. View

13.

Reiter J, Makohon-Moore A, Gerold J, Heyde A, Attiyeh M, Kohutek Z . Minimal functional driver gene heterogeneity among untreated metastases. Science. 2018; 361(6406):1033-1037. PMC: 6329287. DOI: 10.1126/science.aat7171. View

14.

Martin-Perez M, Urdiroz-Urricelqui U, Bigas C, Benitah S . The role of lipids in cancer progression and metastasis. Cell Metab. 2022; 34(11):1675-1699. DOI: 10.1016/j.cmet.2022.09.023. View

15.

Karno B, Edwards D, Chen J . Metabolic control of cancer metastasis: role of amino acids at secondary organ sites. Oncogene. 2023; 42(47):3447-3456. PMC: 11323979. DOI: 10.1038/s41388-023-02868-3. View

16.

Warburg O . On respiratory impairment in cancer cells. Science. 1956; 124(3215):269-70. View

17.

Loo S, Toh L, Xie W, Pathak E, Tan W, Ma S . Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Sci Adv. 2021; 7(41):eabh2443. PMC: 8494440. DOI: 10.1126/sciadv.abh2443. View